Document Detail


PEGylated albumin-heme as an oxygen-carrying plasma expander: Exchange transfusion into acute anemia rat model.
MedLine Citation:
PMID:  16678256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Poly(ethylene glycol) (PEG) conjugated recombinant human serum albumin (HSA) incorporating the synthetic iron-porphyrin (FeP) [PEGylated albumin-heme, PEG(HSA-FeP)] is a unique albumin-based oxygen carrier as a red blood cell (RBC) substitute. The physiological responses to an exchange transfusion with PEG(HSA-FeP) into an acute anemia rat model were investigated. After a 65% isovolemic hemodilution with HSA, a 30% volume of the circulatory blood was withdrawn, affording a hemorrhaged state. The circulation parameters, blood parameters, renal cortical oxygen partial pressure [PtO(2)(R)], and muscle tissue oxygen partial pressure [PtO(2)(M)] were continuously monitored. The intravenous infusion of PEG(HSA-FeP) restored the reduced levels of the mean arterial pressure, heart rate, respiration rate, mixed venous PO(2), and arterial PCO(2). The increased arterial PO(2) and pH also returned to their basal values. These effects were almost to the same extent as those observed after the administration of the RBC suspension. The relatively low recovery in PtO(2)(R) and PtO(2)(M) might be due to the Langmuir-type oxygen binding profile of PEG(HSA-FeP) (Hill coefficient: 1.0). All the animals survived during the experiments. In contrast, those injected with HSA died within 41 min. The PEG(HSA-FeP) solution is an oxygen-carrying plasma expander which can be used as a resuscitative fluid for hemorrhagic shock.
Authors:
Yubin Huang; Teruyuki Komatsu; Hisashi Yamamoto; Hirohisa Horinouchi; Koichi Kobayashi; Eishun Tsuchida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-04
Journal Detail:
Title:  Biomaterials     Volume:  27     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  4477-83     Citation Subset:  IM    
Affiliation:
Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169 8555, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Albumins / chemistry*
Anemia / therapy*
Animals
Blood Pressure
Blood Substitutes*
Disease Models, Animal*
Heart Rate
Heme / chemistry*
Oxygen / chemistry*
Polyethylene Glycols / chemistry*
Rats
Chemical
Reg. No./Substance:
0/Albumins; 0/Blood Substitutes; 0/Polyethylene Glycols; 14875-96-8/Heme; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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