| PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity. | |
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MedLine Citation:
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PMID: 15162212 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water. |
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Authors:
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Katerina Cernovská; Miriam Kemter; Hans-Christoph Gallmeier; Petra Rzepecki; Thomas Schrader; Burkhard König |
Publication Detail:
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Type: Journal Article Date: 2004-05-11 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 2 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-26 Completed Date: 2004-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 1603-11 Citation Subset: - |
Affiliation:
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Institut für Organische Chemie, Universität Regensburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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