Document Detail


PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity.
MedLine Citation:
PMID:  15162212     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.
Authors:
Katerina Cernovská; Miriam Kemter; Hans-Christoph Gallmeier; Petra Rzepecki; Thomas Schrader; Burkhard König
Publication Detail:
Type:  Journal Article     Date:  2004-05-11
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  2     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-26     Completed Date:  2004-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1603-11     Citation Subset:  -    
Affiliation:
Institut für Organische Chemie, Universität Regensburg, Germany.
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