Document Detail

PEEP-masks in patients with severe obstructive pulmonary disease: a negative report.
MedLine Citation:
PMID:  2111249     Owner:  NLM     Status:  MEDLINE    
Positive pressure during expiration by face masks applied by the patient has gained wide acceptance in the treatment of chronic bronchitis, but the efficacy is still unproven. The effect of 6 months of treatment with PEEP-masks (positive end-expiratory pressure) was therefore studied in 47 patients with severe irreversible obstructive pulmonary disease (forced expiratory volume in one second (FEV1) about 1 l), and mucus hypersecretion. Patients were double-blindly randomized to at least 45 min daily treatment with PEEP-masks with either 10 or 0 cm water pressure. After 6 months of treatment, no statistical difference was found between the two groups in change of median values (month 6 - month 0) of FEV1, forced vital capacity (FVC), arterial oxygen tension (PaO2), amount of sputum or dyspnoea. Median values of arterial carbon dioxide tension (PaCO2) decreased significantly (0.03 kPa) in the placebo group. Cough intensity and dyspnoea during walking on staircases improved significantly in the placebo group. No difference among groups was found in number of days bedridden, hospitalized, number of exacerbations or antibiotic consumption. We conclude, that the use of PEEP-masks in these patients is without clinical documentation and cannot be recommended.
H R Christensen; K Simonsen; P Lange; P Clementsen; J P Kampmann; K Viskum; J Heideby; U Koch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The European respiratory journal     Volume:  3     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-27     Completed Date:  1990-06-27     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Dept. P of Pulmonary Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Bed Rest
Carbon Dioxide / blood
Double-Blind Method
Dyspnea / physiopathology
Length of Stay
Lung Diseases, Obstructive / blood,  physiopathology,  therapy*
Middle Aged
Oxygen / blood
Positive-Pressure Respiration*
Randomized Controlled Trials as Topic
Respiratory Function Tests
Reg. No./Substance:
0/Anti-Bacterial Agents; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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