Document Detail

PEEP-induced pulmonary vasoconstriction in neonatal piglets: analysis by pressure-flow curves.
MedLine Citation:
PMID:  10406045     Owner:  NLM     Status:  MEDLINE    
We analyzed the effect of two levels of positive end-expiratory pressure (PEEP: 10 and 15 cm H2O) on pulmonary hemodynamics in neonatal piglet lungs isolated in situ and perfused extracorporeally using pulmonary artery pressure-flow (Pa/Q) relationships. Pulmonary artery pressure (Pa) was measured at flow rates of 50, 75, 100, 125, and 150 mL/kg/min. Pa/Q relationship was evaluated by the slope of the Pa/Q plot and the zero-flow intercept pressure (Pi). Pa/Q relationship with PEEP was studied before and after verapamil. Both levels of PEEP increased the slope of the Pa/Q plot and Pi. PEEP of 15 cm H2O resulted in a steeper slope and a higher Pi compared to 10 cm H2O of PEEP (P < 0.05). Verapamil abolished the increase in slope of the pulmonary artery Pa/Q plot but did not affect the increase in Pi with PEEP. The increase in Pi was equal to the increase in mean airway pressure. Verapamil did not affect changes in ventilatory parameters. PEEP increased pulmonary vascular resistance (PVR) both by increasing the Pi, which reflects the weighted average of the critical closing pressure, and represents a "Starling resistor" phenomenon, and an increase in the slope of the P-Q plot, reflecting an increase in pulmonary vascular tone. This response may be unique to the neonatal pulmonary circulation.
S T Venkataraman; J W Allen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  28     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Analysis of Variance
Animals, Newborn
Disease Models, Animal
Hemodynamics / physiology
Linear Models
Positive-Pressure Respiration / adverse effects*
Pulmonary Artery*
Pulmonary Wedge Pressure
Reference Values
Sensitivity and Specificity
Vascular Resistance / physiology*
Vasoconstriction / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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