Document Detail


PECAM-1: old friend, new partners.
MedLine Citation:
PMID:  14519385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The maintenance of vascular function is of paramount importance to an organism's existence. PECAM-1 (CD31), first thought of as a marker for endothelia, has been shown to be an important scaffolding molecule involved in several signaling pathways. Recent studies have demonstrated an even wider range of functions for this versatile molecule including participation in maintenance of adherens junction integrity and permeability, organization of the intermediate filament cytoskeleton, regulation of catenin localization and transcriptional activities, participation in STAT isoform signaling, control of apoptotic events, and modulation of cardiac cushion development.
Authors:
Neta Ilan; Joseph A Madri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  15     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-01     Completed Date:  2004-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-24     Citation Subset:  IM    
Affiliation:
Department of Vascular Biology, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adherens Junctions / metabolism*
Animals
Antigens, CD31 / metabolism*
Apoptosis / physiology
Capillary Permeability / physiology*
Cell Adhesion Molecules / metabolism
Cytoskeletal Proteins / metabolism*
DNA-Binding Proteins / metabolism
Humans
Intermediate Filaments / metabolism
Milk Proteins*
Models, Molecular
Phosphorylation
Protein Structure, Tertiary
STAT5 Transcription Factor
Signal Transduction / physiology*
Trans-Activators / metabolism*
Vascular Endothelial Growth Factor A / metabolism
alpha Catenin
beta Catenin
Grant Support
ID/Acronym/Agency:
P01-KD38979//PHS HHS; R01-HL51018/HL/NHLBI NIH HHS; R37-HL28373/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD31; 0/CTNNA1 protein, human; 0/CTNNB1 protein, human; 0/Cell Adhesion Molecules; 0/Cytoskeletal Proteins; 0/DNA-Binding Proteins; 0/Milk Proteins; 0/STAT5 Transcription Factor; 0/Trans-Activators; 0/Vascular Endothelial Growth Factor A; 0/alpha Catenin; 0/beta Catenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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