Document Detail

PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes.
MedLine Citation:
PMID:  15591244     Owner:  NLM     Status:  MEDLINE    
The plasma membrane of epithelial cells is subdivided into two physically separated compartments known as the apical and basolateral membranes. To obtain directional transepithelial solute transport, membrane transporters (i.e., ion channels, cotransporters, exchangers, and ion pumps) need to be targeted selectively to either of these membrane domains. In addition, the transport properties of an epithelial cell will be maintained only if these membrane transporters are retained and properly regulated in their specific membrane compartments. Recent reports have indicated that PDZ domain-containing proteins play a dual role in these processes and, in addition, that different apical and basolateral PDZ proteins perform similar tasks in their respective membrane domains. First, although PDZ-based interactions are dispensable for the biosynthetic targeting to the proper membrane domain, the PDZ network ensures that the membrane proteins are efficiently retained at the cell surface. Second, the close spatial positioning of functionally related proteins (e.g., receptors, kinases, channels) into a signal transduction complex (transducisome) allows fast and efficient control of membrane transport processes.
Bert Brône; Jan Eggermont
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American journal of physiology. Cell physiology     Volume:  288     ISSN:  0363-6143     ISO Abbreviation:  Am. J. Physiol., Cell Physiol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901225     Medline TA:  Am J Physiol Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  C20-9     Citation Subset:  IM    
Laboratory of Physiology, Katholieke Universiteit Leuven, Campus Gasthuisberg O & N, Leuven, Belgium.
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MeSH Terms
Carrier Proteins / chemistry,  metabolism*
Cell Polarity / physiology*
Epithelial Cells / cytology,  metabolism*
Membrane Proteins / chemistry,  metabolism*
Protein Structure, Tertiary
Reg. No./Substance:
0/Carrier Proteins; 0/Membrane Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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