Document Detail

PDGF-B induces a homogeneous class of oligodendrogliomas from embryonic neural progenitors.
MedLine Citation:
PMID:  19165863     Owner:  NLM     Status:  MEDLINE    
We describe the generation of mouse gliomas following the overexpression of PDGF-B in embryonic neural progenitors. Our histopathological, immunohistochemical and genome-wide expression analyses revealed a surprising uniformity among PDGF-B induced tumors, despite they were generated by transducing a highly heterogeneous population of progenitor cells known for their ability to produce all the cell types of the central nervous system. Comparison of our microarray data with published gene expression data sets for many different murine neural cell types revealed a closest correlation between our tumor cells and oligodendrocyte progenitor cells, confirming definitively that PDGF-B-induced gliomas are pure oligodendrogliomas. Importantly, we show that this uniformity is likely due to the ability of PDGF-B overexpression to respecify competent embryonic neural precursors toward the oligodendroglial lineage, providing evidence that the transforming activity of PDGF-B is influenced by the developmental potential of the targeted cells. Interestingly, we found that PDGF-B-induced tumors harbor different proliferating cell populations. However only PDGF-B-overexpressing cells are tumorigenic, indicating that paracrine signaling from the tumor is unable to transform bystander cells.
Irene Appolloni; Filippo Calzolari; Evelina Tutucci; Sara Caviglia; Marta Terrile; Giorgio Corte; Paolo Malatesta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  124     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-04-14     Revised Date:  2010-12-08    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2251-9     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Department of Genic Transfer, National Institute for Cancer Research (IST), IRCCS, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
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MeSH Terms
Brain Neoplasms / metabolism,  pathology*
Embryonic Stem Cells / metabolism,  pathology*
Mice, Inbred C57BL
Oligodendroglioma / metabolism,  pathology*
Oligonucleotide Array Sequence Analysis
Proto-Oncogene Proteins c-sis / metabolism,  physiology*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-sis
Erratum In:
Int J Cancer. 2011 Jan 15;128(2):e1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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