| PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans. | |
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MedLine Citation:
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PMID: 23143519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states. |
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Authors:
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Arantza Barrios; Rajarshi Ghosh; Chunhui Fang; Scott W Emmons; Maureen M Barr |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-11 |
Journal Detail:
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Title: Nature neuroscience Volume: 15 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-28 Completed Date: 2013-01-29 Revised Date: 2013-05-13 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1675-82 Citation Subset: IM |
Affiliation:
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Department of Genetics, Rutgers University, Piscataway, New Jersey, USA. a.barrios@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Caenorhabditis elegans / metabolism, physiology* Caenorhabditis elegans Proteins / metabolism, physiology* Disorders of Sex Development / genetics, metabolism, physiopathology Exploratory Behavior / physiology Female Ligands Male Nerve Net / metabolism, physiology* Neuropeptides / metabolism, physiology* Receptors, G-Protein-Coupled / metabolism, physiology* Sexual Behavior, Animal / physiology* Signal Transduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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2R01DK059418/DK/NIDDK NIH HHS; R01 DK059418/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Ligands; 0/Neuropeptides; 0/PDFR-1 protein, C elegans; 0/Receptors, G-Protein-Coupled |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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