Document Detail


PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.
MedLine Citation:
PMID:  23760497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PDCD2 is an evolutionarily conserved eukaryotic protein with unknown function. The Drosophlia PDCD2 ortholog Zfrp8 has an essential function in fly hematopoiesis. Zfrp8 mutants exhibit marked lymph gland hyperplasia that results from increased proliferation of partially differentiated hemocytes, suggesting Zfrp8 may participate in cell growth. Based on the above observations we have focused on the role of PDCD2 in human cancer cell proliferation and hypothesized that aberrant PDCD2 expression may be characteristic of human malignancies. We report that PDCD2 is highly expressed in human acute leukemia cells as well as in normal hematopoietic progenitors. PDCD2 knockdown in cancer cells impairs their proliferation, but not viability relative to parental cells, supporting the notion that PDCD2 overexpression facilitates cancer cell growth. Prospective analysis of PDCD2 in acute leukemia patients indicates PDCD2 RNA expression correlates with disease status and is a significant predictor of clinical relapse. PDCD2's role in cell proliferation and its high expression in human malignancies make it an attractive, novel potential molecular target for new anti-cancer therapies.
Authors:
Nora Barboza; Svetlana Minakhina; Daniel J Medina; Binaifer Balsara; Sonya Greenwood; Lien Huzzy; Arnold B Rabson; Ruth Steward; Dale G Schaar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer biology & therapy     Volume:  14     ISSN:  1555-8576     ISO Abbreviation:  Cancer Biol. Ther.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2014-01-14     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101137842     Medline TA:  Cancer Biol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Apoptosis Regulatory Proteins / genetics,  metabolism*
Cell Line, Tumor
Cell Proliferation*
Gene Expression
Gene Knockdown Techniques
Hematopoietic Stem Cells / metabolism
Humans
Leukemia, Myeloid, Acute / metabolism*,  pathology
Neoplasm Recurrence, Local / metabolism*
Prospective Studies
RNA, Messenger / genetics,  metabolism
Tumor Markers, Biological / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/PDCD2 protein, human; 0/RNA, Messenger; 0/Tumor Markers, Biological
Comments/Corrections

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