Document Detail


PDA workshop on "Quality by Design for Biopharmaceuticals: Concepts and Implementation", May 21-22, 2007, Bethesda, Maryland.
MedLine Citation:
PMID:  19055233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Janet Woodcock, MD, Deputy Commissioner for Operations/Chief Medical Officer at FDA, closed the workshop. She stated that, "QbD represents an evolution and not a revolution" that is in response to the increasing cost pressures on both the regulatory agencies and industry to control the escalation of drug prices. She acknowledged that the successful implementation will require efforts and cooperation between industry and the FDA. She also said that the realization of the full benefits of implementing QbD will require changes in the way industry operates and in the regulations, and thus will take time. The issue of the lack of harmonization of these concepts across different regulatory agencies was recognized as a significant deterrent for companies to implement QbD. FDA is working with other major regulatory agencies to seek better alignment. The Agency also acknowledged that the concepts and associated flexibility of QbD has not yet reached the inspectional arena. The establishment of a "Pharmaceutical Inspectorate" that would standardize an approach and hopefully become an international organization was suggested as a potential outcome of the ongoing efforts.
Authors:
Anurag S Rathore; Rebecca Devine
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Publication Detail:
Type:  Congresses    
Journal Detail:
Title:  PDA journal of pharmaceutical science and technology / PDA     Volume:  62     ISSN:  1079-7440     ISO Abbreviation:  PDA J Pharm Sci Technol     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439538     Medline TA:  PDA J Pharm Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-90     Citation Subset:  IM    
Affiliation:
Amgen Inc., Thousand Oaks, CA 91320, USA. asrathore@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical
Drug Compounding
Drug Design*
Drug Industry
Interdisciplinary Communication
Pharmaceutical Preparations / chemistry*
Quality Control
Reproducibility of Results
Technology, Pharmaceutical / methods*,  standards
Terminology as Topic
United States
United States Food and Drug Administration
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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