| PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity. | |
| | |
MedLine Citation:
|
PMID: 20445553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Langerhans cells (LCs) are known as "sentinels" of the immune system that function as professional antigen-presenting cells (APCs) after migration to draining lymph node. LCs are proposed to have a role in tolerance and the resolution of cutaneous immune responses. The Programmed Death-1 (PD-1) receptor and its ligands, PD-L1 and PD-L2, are a co-inhibitory pathway that contributes to the negative regulation of T-lymphocyte activation and peripheral tolerance. Surprisingly, we found PD-1 to be expressed on immature LCs (iLCs) in situ. PD-1 engagement on iLCs reduced IL-6 and macrophage inflammatory protein (MIP)-1alpha cytokine production in response to TLR2 signals but had no effect on LC maturation. PD-L1 and PD-L2 were expressed at very low levels on iLCs. Maturation of LCs upon migration from epidermis led to loss of PD-l expression and gain of high expression of PD-L1 and PD-L2 as well as co-stimulatory molecules. Blockade of PD-L1 and/or PD-L2 on migratory LCs (mLCs) and DDCs enhanced T-cell activation, as has been reported for other APCs. Thus the PD-1 pathway is active in iLCs and inhibits iLC activities, but expression of receptor and ligands reverses upon maturation and PD-L1 and PD-L2 on mLC function to inhibit T-cell responses. |
| | |
Authors:
|
Victor Peña-Cruz; Sean M McDonough; Felipe Diaz-Griffero; Christopher P Crum; Ruben D Carrasco; Gordon J Freeman |
Related Documents
:
|
15654963 - Tgfbeta inhibits cd1d expression on dendritic cells. 17130243 - Murine cxcl14 is dispensable for dendritic cell function and localization within periph... 16374213 - Immune reconstitution inflammatory syndrome in hiv. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-06 |
Journal Detail:
|
Title: The Journal of investigative dermatology Volume: 130 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-16 Completed Date: 2010-09-16 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 2222-30 Citation Subset: IM |
Affiliation:
|
Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigen Presentation
/
immunology* Antigens, CD / metabolism* Antigens, CD80 / metabolism Antigens, CD86 / metabolism Apoptosis Regulatory Proteins / metabolism* Cell Communication / immunology Cell Differentiation / immunology Cell Movement / immunology* Cytokines / metabolism Humans Immunoglobulins / metabolism Immunophenotyping Intercellular Signaling Peptides and Proteins / metabolism* Jurkat Cells Langerhans Cells / immunology, metabolism* Ligands Lymphocyte Activation / immunology Membrane Glycoproteins / metabolism Signal Transduction / immunology Toll-Like Receptor 2 / agonists, metabolism Up-Regulation / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
A1056299//PHS HHS; A108080192//PHS HHS; BAA-05-11//PHS HHS; HHSN266200500030C//PHS HHS; P01 AI056299-06A17716/AI/NIAID NIH HHS; P01 AI056299-077716/AI/NIAID NIH HHS; P01 AI080192-019001/AI/NIAID NIH HHS; P01 AI080192-029001/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, CD86; 0/Apoptosis Regulatory Proteins; 0/B7-DC antigen; 0/CD274 protein, human; 0/CD83 antigen; 0/CD86 protein, human; 0/Cytokines; 0/Immunoglobulins; 0/Intercellular Signaling Peptides and Proteins; 0/Ligands; 0/Membrane Glycoproteins; 0/TLR2 protein, human; 0/Toll-Like Receptor 2; 146588-21-8/PDCD1 protein, human |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and C...
Next Document: IL-17A Has an Important Role in the Acute Attacks of Beh??et's Disease.