Document Detail

PCNA and P53 expression in relation to clinicopathological features of oral papilloma.
MedLine Citation:
PMID:  11820603     Owner:  NLM     Status:  MEDLINE    
Although papilloma is the most frequent benign epithelial tumour of oral cavity, its biological potential for malignant transformation is still to be evaluated. The aim of the study was to correlate PCNA and P53 expression in 55 oral papillomas with some clinicopathological variables. The tissue samples were stained with H+E and by immunohistochemistry for PCNA and P53 protein. Staining patterns were assessed semiquantitatively and correlated with each other and grade of tumour epithelial dysplasia, tumour size, localization well patient age and sex. PCNA immunostaining was positive 43 (78%) oral papillomas. P53 immunohistochemical reaction was positive in 38 (69%) out of 55 epithelial tumours. Positive relationship between PCNA and P53 expression was observed as well as between PCNA immunostaining and grade of epithelial dysplasia. There was no statistically significant relationships between PCNA, P53 immunohistochemical positivity and papilloma size, site, patient age and sex. The results of this study suggest that immunohistochemical P53 overexpression is valuable marker of early neoplastic transformation and together with PCNA are presumed predictors for malignant transformation of oral papillomas.
M Sulkowska; W Famulski; A Stasiak-Barmuta; I Kasacka; M Koda; L Chyczewski; S Sulkowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  39 Suppl 2     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-31     Completed Date:  2002-06-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  193-4     Citation Subset:  IM    
Department of Clinical Pathology, Medical Academy, Białystok, Poland.
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MeSH Terms
Immunoenzyme Techniques
Middle Aged
Mouth Neoplasms / chemistry*,  pathology*
Papilloma / chemistry*,  pathology*
Predictive Value of Tests
Proliferating Cell Nuclear Antigen / analysis*
Tumor Markers, Biological / analysis
Tumor Suppressor Protein p53 / analysis*
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53

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