| PCDD and PCDF depletion in milk from dairy cows according to the herd metabolic scenario. | |
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MedLine Citation:
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PMID: 18462776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High level of PCDD+PCDF contamination in bulk milk (9.7 pg WHO-TE g(-1) fat) from 1604 Holstein Fresian lactacting cows was observed just four weeks after the beginning of their exposure to a feed supplement contaminated at 10.4 ng WHO-TE kg(-1) dry matter. In-farm produced hay and silage showed levels not exceeding 0.2 ng WHO-TE kg(-1) dry matter. After the supplement withdrawal, it was possible to monitor the depletion phase for a following 75-day period in milk, until the levels dropped well below 3.0 pg WHO-TE g(-1) fat, the EU regulatory Maximum Residue Level for PCDD+PCDF. During this phase, the half-life was calculated as 17+/-3 days, on WHO-TEQ basis. The full availability of farm data on both cow nutrition and milk production allowed the calculation of the carry-over rate (COR) (PCDD+PCDF milk excretion vs. feed), which was 46% at the end of the exposure. This COR value is justified from the main TE contribution of Penta-CDD and -CDF congeners (63%), and the half-life is among the shortest of all those described in the literature both for experimental and naturally-exposed dairy cows. A fugacity-based model predicts a bulk milk contamination of 5 pg WHO-TE g(-1) fat, compared to the 10 pg WHO-TE g(-1) fat level observed. Such findings are discussed in light of the lactation and metabolic status of the herd for which the transition period, characterised by a negative metabolic energy balance and a consequent adipose tissue mobilization, could play a relevant role. |
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Authors:
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Gianfranco Brambilla; Igor Fochi; Michele Falce; Stefania Paola De Filippis; Alessandro Ubaldi; Alessandro di Domenico |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-06 |
Journal Detail:
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Title: Chemosphere Volume: 73 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2008-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
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Languages: eng Pagination: S216-9 Citation Subset: IM |
Affiliation:
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Italian National Institute for Health, Toxicological Chemistry Unit, Viale Regina Elena, 299, I-00161 Rome, Italy. g.brambi@iss.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Benzofurans / chemistry, metabolism* Cattle Dairying* Food Contamination Linear Models Milk / metabolism* Tetrachlorodibenzodioxin / analogs & derivatives*, chemistry, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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