Document Detail


PC-SPES: herbal formulation for prostate cancer.
MedLine Citation:
PMID:  12350462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PC-SPES is a potent eight-herb formulation sold directly to consumers; it has promising efficacy in the treatment of prostate cancer (CaP). The product induces a castrate status in most, if not all, men, resulting in a 50% or greater prostate-specific antigen reduction in the great majority of men with androgen-dependent CaP and in more than one half of the men with androgen-independent CaP. The duration of response is not yet clear. The efficacy of PC-SPES appears to exceed that of androgen ablation alone, but is not necessarily separate from an estrogenic effect. Common side effects include gynecomastia, nipple tenderness, loss of libido, and impotency; uncommon side effects include a 4% incidence of thromboembolic phenomena, but also two reports of bleeding diatheses. The mechanisms of action may involve downregulation of the androgen receptor, induction of apoptosis by way of inhibition of the bcl-2 gene, and increased expression of p53. Two marker compounds in PC-SPES are baicalin and oridonin, both of which exhibit antiproliferative effects in CaP cell lines. Thousands of men are currently obtaining this nonprescription medicine, and physicians should ask patients specifically about its use. PC-SPES is of great interest in men with androgen-independent CaP, an area in which future research should be primarily directed.
Authors:
Leonard S Marks; Robert S DiPaola; Peter Nelson; Sophie Chen; David Heber; Arie S Belldegrun; Franklin C Lowe; John Fan; Floyd E Leaders; Allan J Pantuck; Varro E Tyler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Urology     Volume:  60     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2002-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-75; discussion 376-7     Citation Subset:  IM    
Affiliation:
Urological Sciences Research Foundation, Culver City, California 90232, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / therapeutic use*
Drugs, Chinese Herbal / therapeutic use*
Humans
Male
Plant Extracts / therapeutic use*
Prostate-Specific Antigen / blood
Prostatic Neoplasms / blood,  drug therapy*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/Plant Extracts; 0/herbal preparation PC-SPES; EC 3.4.21.77/Prostate-Specific Antigen
Comments/Corrections
Comment In:
Urology. 2003 Jun;61(6):1292   [PMID:  12809931 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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