| PC-1 genotype and IRS response to exercise training. | |
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MedLine Citation:
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PMID: 17990211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate whether the efficacy of exercise training as a means of insulin resistance syndrome (IRS) treatment is dependent on the PC-1 gene K121Q variants. A population of 84 abdominally obese Korean women was analyzed prospectively. Before and after a 12-week exercise (walking) training program, indices of body fatness including body mass index, percent body fat, and waist circumference, and cardiorespiratory fitness were measured. Total cholesterol (TC), triacylglycerol, high-density lipoprotein cholesterol (HDLC), glucose, and insulin were measured in fasting venous blood. At baseline, KK individuals had significantly lower waist circumference (p = 0.019) and TC (p = 0.001) than KQ/QQ individuals did. In particular, compared with KQ/QQ individuals, KK individuals had significantly greater reductions in body weight (p = 0.002), BMI (p = 0.032), and fasting insulin (p = 0.042), and a greater increase in HDLC (p = <0.001), following the 12-week walking exercise program. This study suggests that the PC-1 gene K121Q polymorphism may modulate responses of IRS to exercise training, at least in this population. |
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Authors:
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S Park; T Han; T Son; H-S Kang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-13 |
Journal Detail:
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Title: International journal of sports medicine Volume: 29 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 294-9 Citation Subset: IM |
Affiliation:
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School of Sport Science, Sungkyunkwan University, Jangan-Gu, Suwon, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asian Continental Ancestry Group / genetics Body Mass Index Body Weight / physiology Cholesterol, HDL / blood Exercise / physiology* Female Genotype* Humans Insulin / blood Insulin Resistance / physiology* Korea Middle Aged Obesity / physiopathology, rehabilitation Phosphoric Diester Hydrolases / genetics* Prospective Studies Pyrophosphatases / genetics* Syndrome Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 11061-68-0/Insulin; EC 3.1.4.-/Phosphoric Diester Hydrolases; EC 3.1.4.1/ectonucleotide pyrophosphatase phosphodiesterase 1; EC 3.6.1.-/Pyrophosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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