Document Detail

PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.
MedLine Citation:
PMID:  12640039     Owner:  NLM     Status:  MEDLINE    
A novel member of the poly(ADP-ribose) polymerase (PARP) family, hPARP-3, is identified here as a core component of the centrosome. hPARP-3 is preferentially localized to the daughter centriole throughout the cell cycle. The N-terminal domain (54 amino acids) of hPARP-3 is responsible for its centrosomal localization. Full-length hPAPR-3 (540 amino acids, with an apparent mass of 67 kDa) synthesizes ADP-ribose polymers during its automodification. Overexpression of hPARP-3 or its N-terminal domain does not influence centrosomal duplication or amplification but interferes with the G1/S cell cycle progression. PARP-1 also resides for part of the cell cycle in the centrosome and interacts with hPARP-3. The presence of both PARP-1 and PARP-3 at the centrosome may link the DNA damage surveillance network to the mitotic fidelity checkpoint.
Angélique Augustin; Catherine Spenlehauer; Hélène Dumond; Josiane Ménissier-De Murcia; Matthieu Piel; Anne-Catherine Schmit; Françoise Apiou; Jean-Luc Vonesch; Michael Kock; Michel Bornens; Gilbert De Murcia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cell science     Volume:  116     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2004-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1551-62     Citation Subset:  IM    
Unité 9003 du CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant, 67400 Illkirch, France.
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MeSH Terms
3T3 Cells
Amino Acid Sequence
Base Sequence
CHO Cells
Cell Cycle Proteins / genetics,  metabolism*
Cell Division / drug effects
Cell Line
Cell Survival / drug effects,  genetics
Centrioles / metabolism*
G1 Phase / drug effects
Hela Cells
Hydroxyurea / pharmacology
In Situ Hybridization, Fluorescence / methods
Molecular Sequence Data
Poly(ADP-ribose) Polymerases / antagonists & inhibitors,  genetics,  metabolism*
S Phase / drug effects
Sequence Alignment
Sequence Homology, Amino Acid
Reg. No./Substance:
0/Cell Cycle Proteins; 127-07-1/Hydroxyurea; EC protein, human; EC Polymerases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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