| PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. | |
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MedLine Citation:
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PMID: 19147789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(ADP-ribos)ylation is one of the longest-known but most enigmatic posttranslational modifications transducing specific signals. The enzyme responsible for the majority of poly(ADP-ribose) polymerization in cells, PARP-1, promotes DNA repair but also mediates a caspase-independent form of apoptosis in response to stressors such as irradiation. However, the biologic function of most other PARPs is not known. Macro-PARPs constitute one branch of the large family of PARP-like proteins also designated as B aggressive lymphoma proteins (BAL1, 2a/2b, 3, or PARP-9, PARP-14, and PARP-15). To elucidate biologic role(s) of a BAL-family macro-PARP, we analyzed mice deficient in PARP-14, a binding partner of the IL-4-induced transcription factor Stat6. We show here that PARP-14 plays a fundamental role mediating protection against apoptosis in IL-4-treated B cells, including that after DNA damage, and mediates IL-4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis. Collectively, the results establish that PARP-14 mediates regulation of gene expression and lymphocyte physiology by IL-4 and has a function distinct from PARP-1. Furthermore, the findings suggest mechanisms by which BAL-family proteins might influence pathologic processes involving B lymphocytes. |
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Authors:
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Sung Hoon Cho; Shreevrat Goenka; Tiina Henttinen; Prathyusha Gudapati; Arja Reinikainen; Christine M Eischen; Riitta Lahesmaa; Mark Boothby |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-01-15 |
Journal Detail:
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Title: Blood Volume: 113 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-13 Completed Date: 2009-04-13 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 2416-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation / drug effects, genetics Apoptosis / genetics, immunology B-Lymphocytes / drug effects, metabolism, physiology* Cell Differentiation / drug effects, genetics Cell Survival / genetics Female Immunoglobulin A / immunology Interleukin-4 / pharmacology Mice Mice, Inbred C57BL Mice, Knockout Multigene Family Neoplasm Proteins / genetics, metabolism, physiology Poly(ADP-ribose) Polymerases / chemistry, genetics, metabolism, physiology* Sequence Homology |
| Grant Support | |
ID/Acronym/Agency:
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AI068149/AI/NIAID NIH HHS; GM071735/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coast6 protein, mouse; 0/Immunoglobulin A; 0/Neoplasm Proteins; 207137-56-2/Interleukin-4; EC 2.4.2.30/Parp-9 protein, mouse; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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