| PAPP-A, free β-hCG, and early fetal growth identify two pathways leading to preterm delivery. | |
| | |
MedLine Citation:
|
PMID: 20721873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate early fetal growth and the biomarkers, pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotrophin (β-hCG), in relation to preterm delivery. METHODS: A cohort study of 9450 singleton pregnant women who attended the prenatal screening program at Aarhus University Hospital between January 2005 and December 2007, was conducted. PAPP-A and free β-hCG were measured in the first trimester. Early fetal growth was estimated by (GA(20)- GA(12))/Days(calendar), where GA(12) reflects the gestational age in days calculated from the crown-rump length at a 12-week scan, GA(20) reflects the gestational age in days calculated from the biparietal diameter at a 20-week scan, and Days(calendar) is the number of calendar days between the two scans. RESULTS: Low PAPP-A and low free β-hCG were significantly associated with preterm delivery (<37 weeks). The association was even stronger when low PAPP-A and slow early fetal growth were combined, resulting in an adjusted odds ratio of 3.8 (95% CI, 1.6-8.7). Fast early fetal growth, but neither high PAPP-A nor high free β-hCG, was significantly associated with preterm delivery. CONCLUSION: Two different biological pathways leading to spontaneous preterm delivery are suggested: fast early fetal growth and the combination of low PAPP-A and slow early fetal growth. |
| | |
Authors:
|
Ida Kirkegaard; Niels Uldbjerg; Olav Bjørn Petersen; Niels Tørring; Tine Brink Henriksen |
Related Documents
:
|
6980063 - Heterogeneity of the pregnancy-specific beta 1-glycoprotein (sp1). 3273753 - Occult biochemical pregnancy: fact or fiction? 17904953 - Successful continuation of pregnancy after repair of a midgestational uterine rupture w... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-29 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
|
Languages: eng Pagination: 956-63 Citation Subset: IM |
Copyright Information:
|
© 2010 John Wiley & Sons, Ltd. |
Affiliation:
|
Perinatal Epidemiology Research Unit, Aarhus University Hospital, Skejby, Aarhus, Denmark. ida.kirkegaard@ki.au.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biological Markers / blood Chorionic Gonadotropin, beta Subunit, Human / blood* Cohort Studies Crown-Rump Length Denmark / epidemiology Female Fetal Development / physiology* Gestational Age Humans Maternal Age Pregnancy / blood* Pregnancy-Associated Plasma Protein-A / metabolism* Premature Birth / blood*, epidemiology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sixteen years of prenatal consultations for the N370S/N370S Gaucher disease genotype: what have we l...
Next Document: Prenatal diagnosis of polysplenia syndrome associated with increased nuchal translucency.