Document Detail

The PANDORA study: peripheral arterial disease in patients with non-high cardiovascular risk.
MedLine Citation:
PMID:  21298363     Owner:  NLM     Status:  MEDLINE    
Few studies are available with sufficient sample size to accurately describe the prevalence of low ankle-brachial index (ABI) in patients at 'non-high' cardiovascular (CV) risk. The aim of this study was to evaluate the prevalence of asymptomatic peripheral arterial disease (PAD), as determined by using ABI, in this patient population. A non-interventional, cross-sectional, pan-European study was conducted in patients with ≥1 CV risk factor in addition to age, evaluating the prevalence of asymptomatic PAD (ABI ≤ 0.90). Secondary objectives included assessing the prevalence and treatment of CV risk factors. Patients were consecutively recruited during scheduled visits to the physician's office, or were randomly selected by the physician from a list of eligible patients. Patients with diabetes were excluded as this condition was deemed to be a secondary prevention risk. 10,287 patients were enrolled (9,816 evaluable: mean age 64.3 years; 53.5% male). Prevalence of asymptomatic PAD was 17.8% (99% CI 16.84-18.83). Factors significantly associated with asymptomatic PAD included hypertension, age, alcohol intake, family history of coronary heart disease, low levels of high-density lipoprotein-cholesterol, and smoking (p < 0.0001). Patients treated with statins were significantly less likely to have asymptomatic PAD than those who were not (odds ratio 0.62; 95% CI 0.50-0.76; p < 0.0001). Asymptomatic PAD was highly prevalent in patients with non-high CV risk, the majority of whom would not typically be candidates for ABI assessment. These patients should be carefully screened, and ABI measured, so that therapeutic interventions known to diminish their increased CV risk may be offered.
Claudio Cimminiello; Serge Kownator; Jean-Claude Wautrecht; Christos P Carvounis; Stefanus Eliza Kranendonk; Beat Kindler; Mario Mangrella; Claudio Borghi;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-05
Journal Detail:
Title:  Internal and emergency medicine     Volume:  6     ISSN:  1970-9366     ISO Abbreviation:  Intern Emerg Med     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-04-11     Revised Date:  2012-11-13    
Medline Journal Info:
Nlm Unique ID:  101263418     Medline TA:  Intern Emerg Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  509-19     Citation Subset:  IM    
Department of Medicine, Vimercate Hospital, via Cesare Battisti 23, Vimercate (MI) 20059, Italy.
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MeSH Terms
Aged, 80 and over
Ankle Brachial Index
Asymptomatic Diseases*
Cardiovascular Diseases*
Cross-Sectional Studies
Europe / epidemiology
Middle Aged
Peripheral Arterial Disease / epidemiology*
Risk Assessment
Risk Factors
Comment In:
Intern Emerg Med. 2012 Feb;7(1):95   [PMID:  21667070 ]
Intern Emerg Med. 2012 Oct;7(5):485-6   [PMID:  21717233 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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