Document Detail

The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study.
MedLine Citation:
PMID:  25078885     Owner:  NLM     Status:  Publisher    
PROBLEM: Thrombophilia has been postulated to be a contributor to the pathophysiology of recurrent pregnancy loss (RPL). We investigated the role of the plasminogen activator inhibitor type 1 (PAI-1) 4G/5G and angiotensin converting enzyme (ACE) I/D polymorphisms in Korean patients with RPL.
METHOD OF STUDY: Genotyping was performed using the TaqMan assay in 227 RPL patients and 304 controls.
RESULTS: The genotype distributions of both polymorphisms in the RPL group did not differ from those of controls. Because the frequency of being homozygous for ACE D/D and the PAI-I 4G/4G combination has been reported to be significantly higher in RPL patients, this was also analyzed. However, no significant difference was noted; 3.1% of RPL patients had both ACE D/D and PAI-I 4G/4G, as did 4.9% of controls (P = 0.791).
CONCLUSION: The current study suggests that both polymorphisms, either alone or in combination, are not major determinants of the development of RPL in Korean women.
Jin Ju Kim; Young Min Choi; Sung Ki Lee; Kwang Moon Yang; Eun Chan Paik; Hyeon Jeong Jeong; Jong Kwan Jun; Ae Ra Han; Min A Hong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-31
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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