Document Detail


PAF is in the cabal of MLL1-interacting proteins that promote leukemia.
MedLine Citation:
PMID:  20541697     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
MLL1 fusions are among the most potent oncogenic drivers of leukemia development. In recent articles published in Molecular Cell and in Cancer Cell, researchers find that MLL1 fusions are reliant on a physical interaction with the PAF transcription elongation complex for their recruitment to chromatin and, consequently, leukemic transformation.
Authors:
Nancy A Speck; Christopher R Vakoc
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer cell     Volume:  17     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-08-17     Revised Date:  2014-02-07    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-2     Citation Subset:  -    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 AI051427/AI/NIAID NIH HHS; R01 CA104509/CA/NCI NIH HHS

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