| PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. | |
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MedLine Citation:
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PMID: 16369775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the effects of specific platelet-activating factor (PAF) antagonist BN-52021 on intercellular adhesion molecule-1 (ICAM) expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. Thirty male Sprague-Dawley rats were separated into three groups, each containing ten rats. A sham operation was performed in group 1 (control). In group 2 [ischemia-reperfusion (I-R)/untreated], 1-h detorsion of the testis was performed after 6 h of unilateral testicular torsion. In group 3 (I-R/BN-52021), after performing the same surgical procedures as in groups II, BN-52021 was given intravenously at the starting time of reperfusion. In all experimental rats, ipsilateral orchiectomies were performed for histological examination and measuring the tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). MDA values and the testicular injury score decreased and SOD, CAT and GSH-Px values increased in the I-R/BN-52021 treated group compared to in the I-R/untreated group. Most of the specimens in the I-R/BN-52021 treated group showed grade-I testicular injury. However, the injuries in the I-R/untreated rats varied between grades III and IV. An ICAM-1 expression was intensive in the interstitial spaces and basement membrane of the tubuli seminiferi, of testicular tissue in the I-R/untreated group. However, an ICAM-1 expression was mild in the I-R/BN-52021 group. BN-52021 may play an important role in the immunohistochemical expression of adhesion molecule ICAM-1 and may reduce oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. |
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Authors:
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Hulya Ozturk; Hayrettin Ozturk; Yusuf Yagmur |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2005-12-14 |
Journal Detail:
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Title: Pediatric surgery international Volume: 22 ISSN: 0179-0358 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-31 Completed Date: 2006-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
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Languages: eng Pagination: 191-6 Citation Subset: IM |
Affiliation:
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Diyarbakir Children Hospital, Diyarbakir, Turkey. ozturkhayrettin@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Diterpenes / pharmacology*, therapeutic use Fibrinolytic Agents / pharmacology*, therapeutic use Ginkgolides Immunohistochemistry Intercellular Adhesion Molecule-1 / drug effects*, metabolism Lactones / pharmacology*, therapeutic use Male Oxidative Stress / drug effects* Platelet Activating Factor / antagonists & inhibitors* Random Allocation Rats Rats, Sprague-Dawley Reperfusion Injury / drug therapy*, etiology, pathology Spermatic Cord Torsion / complications* |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/Fibrinolytic Agents; 0/Ginkgolides; 0/Lactones; 0/Platelet Activating Factor; 126547-89-5/Intercellular Adhesion Molecule-1; 99796-69-7/ginkgolide B |
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