| PAF-acether induced cardiac dysfunction in the isolated perfused guinea pig heart. | |
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MedLine Citation:
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PMID: 3431598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PAF-acether (1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) has been implicated in a variety of inflammatory and ischaemic disorders (e.g., myocardial ischemia, anaphylactic shock). Recently, the peptide leukotrienes (i.e., LTC4, LTD4) have been shown to mediate the increase in coronary vascular resistance induced by PAF-acether in the isolated perfused rat heart. In isolated perfused guinea pig hearts, PAF-acether produced a dose-dependent increase in coronary perfusion pressure (CPP) and a decrease in contractile force (CF). At 50 pmol/l, PAF increased CPP by 13 +/- 3 mm Hg and decreased CF by 47 +/- 12% in 8 hearts. Radioimmunoassay of the coronary effluent did not detect peptide leukotrienes or thromboxane B2 (TxB2) in response to PAF. Addition of a specific PAF-acether receptor antagonist, CV-6209 (25 nmol/l), blocked the increase in coronary perfusion pressure and decrease in contractile force. OKY-1581 (400 nmol/l), a thromboxane synthetase inhibitor or LY-171,883 (7.3 mumol/l) a leukotriene D4 receptor antagonist, failed to prevent the increase in CPP or the decrease in CF. These data indicate that the PAF-acether induced increase in CPP is not mediated by the peptide leukotrienes or thromboxane A2 (TxA2). Possible mechanisms for the increase in CPP induced by PAF-acether in the isolated perfused guinea pig heart include a direct receptor mediated constriction of coronary resistance vessels, release of a non-eicosanoid coronary constrictor as a mediator of the response, or via enhancement of coronary microvascular permeability. |
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Authors:
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G L Stahl; D J Lefer; A M Lefer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 336 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-03-24 Completed Date: 1988-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 459-63 Citation Subset: IM |
Affiliation:
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Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / physiology* Guinea Pigs Male Methacrylates / pharmacology Platelet Activating Factor / antagonists & inhibitors, physiology* Radioimmunoassay Thromboxane-A Synthase / antagonists & inhibitors Vasoconstriction* |
| Grant Support | |
ID/Acronym/Agency:
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HL-07599/HL/NHLBI NIH HHS; HL-25575/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methacrylates; 0/Platelet Activating Factor; 75987-08-5/2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid; EC 5.3.99.5/Thromboxane-A Synthase |
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