Document Detail

PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  20471595     Owner:  NLM     Status:  MEDLINE    
The volatile phenols, to which Saccharomyces cerevisiae converts from phenylacrylic acids including ferulic acid, p-coumaric acid, and cinnamic acid, generate off-flavors in alcoholic beverages such as beer and wine. Using gene disruptants, transformants and cell-free extracts of these strains, we have verified that the adjacent PAD1 (phenylacrylic acid decarboxylase, YDR538W) and FDC1 (ferulic acid decarboxylase, YDR539W) genes are essential for the decarboxylation of phenylacrylic acids in S. cerevisiae. Pad1p and Fdc1p are homologous with UbiX and UbiD, respectively, in the ubiquinone synthetic pathway of Escherichia coli. However, ubiquinone was detected quantitatively in all of the yeast single-deletion mutants, Delta pad1, Delta fdc1, and double-deletion mutant, Delta pad1 Delta fdc1.
Nobuhiko Mukai; Kazuo Masaki; Tsutomu Fujii; Makoto Kawamukai; Haruyuki Iefuji
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Publication Detail:
Type:  Journal Article     Date:  2009-12-16
Journal Detail:
Title:  Journal of bioscience and bioengineering     Volume:  109     ISSN:  1347-4421     ISO Abbreviation:  J. Biosci. Bioeng.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888800     Medline TA:  J Biosci Bioeng     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  564-9     Citation Subset:  IM    
Copyright Information:
(c) 2009 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan.
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MeSH Terms
Alcoholic Beverages
Carboxy-Lyases / genetics,  metabolism*
Cinnamates / metabolism*
Coumaric Acids / metabolism
Escherichia coli Proteins / metabolism
Saccharomyces cerevisiae / enzymology*,  genetics
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Reg. No./Substance:
0/Cinnamates; 0/Coumaric Acids; 0/Escherichia coli Proteins; 0/Saccharomyces cerevisiae Proteins; 1135-24-6/ferulic acid; 621-82-9/cinnamic acid; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.-/phenylacrylic acid decarboxylase

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