| PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 20471595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The volatile phenols, to which Saccharomyces cerevisiae converts from phenylacrylic acids including ferulic acid, p-coumaric acid, and cinnamic acid, generate off-flavors in alcoholic beverages such as beer and wine. Using gene disruptants, transformants and cell-free extracts of these strains, we have verified that the adjacent PAD1 (phenylacrylic acid decarboxylase, YDR538W) and FDC1 (ferulic acid decarboxylase, YDR539W) genes are essential for the decarboxylation of phenylacrylic acids in S. cerevisiae. Pad1p and Fdc1p are homologous with UbiX and UbiD, respectively, in the ubiquinone synthetic pathway of Escherichia coli. However, ubiquinone was detected quantitatively in all of the yeast single-deletion mutants, Delta pad1, Delta fdc1, and double-deletion mutant, Delta pad1 Delta fdc1. |
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Authors:
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Nobuhiko Mukai; Kazuo Masaki; Tsutomu Fujii; Makoto Kawamukai; Haruyuki Iefuji |
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Publication Detail:
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Type: Journal Article Date: 2009-12-16 |
Journal Detail:
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Title: Journal of bioscience and bioengineering Volume: 109 ISSN: 1347-4421 ISO Abbreviation: J. Biosci. Bioeng. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888800 Medline TA: J Biosci Bioeng Country: Japan |
Other Details:
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Languages: eng Pagination: 564-9 Citation Subset: IM |
Copyright Information:
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(c) 2009 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan. mukai-n-0907@hi.enjoy.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholic Beverages Carboxy-Lyases / genetics, metabolism* Cinnamates / metabolism* Coumaric Acids / metabolism Decarboxylation Escherichia coli Proteins / metabolism Saccharomyces cerevisiae / enzymology*, genetics Saccharomyces cerevisiae Proteins / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cinnamates; 0/Coumaric Acids; 0/Escherichia coli Proteins; 0/Saccharomyces cerevisiae Proteins; 1135-24-6/ferulic acid; 621-82-9/cinnamic acid; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.-/phenylacrylic acid decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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