Document Detail

PACAP modulates the respiratory rhythm generated in the brainstem slice preparation.
MedLine Citation:
PMID:  20217333     Owner:  NLM     Status:  MEDLINE    
Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in breathing control and its absence leads to sudden death of neonatal mice. It has also been shown that exogenous PACAP application increases breathing by activating peripheral chemoreceptors. However, the contribution of the central respiratory network to PACAP activation of breathing has not been yet established. Here, I explore the effect of PACAP on the rhythmic inspiratory activity generated by the preB?tzinger complex (PreB?tC) in the brainstem slice preparation. The results show that PACAP increases, in a concentration-dependent manner, burst frequency and decreases burst amplitude of the respiratory rhythm generated in vitro. In conclusion, PACAP is a neuromodulator of the PreB?tC suggesting that alterations in such neuromodulation might be involved in the sudden infant death-like phenotype.
Fernando Pe?a
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  669     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Departamento de Farmacobiolog?a, Cinvestav-IPN, M?xico, DF, M?xico.
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MeSH Terms
Brain Stem / drug effects*,  physiology*
Dose-Response Relationship, Drug
Neurotransmitter Agents / pharmacology
Pituitary Adenylate Cyclase-Activating Polypeptide / pharmacology*
Respiratory Mechanics / drug effects*,  physiology*
Time Factors
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Pituitary Adenylate Cyclase-Activating Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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