| PACAP modulates the respiratory rhythm generated in the brainstem slice preparation. | |
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MedLine Citation:
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PMID: 20217333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in breathing control and its absence leads to sudden death of neonatal mice. It has also been shown that exogenous PACAP application increases breathing by activating peripheral chemoreceptors. However, the contribution of the central respiratory network to PACAP activation of breathing has not been yet established. Here, I explore the effect of PACAP on the rhythmic inspiratory activity generated by the preB?tzinger complex (PreB?tC) in the brainstem slice preparation. The results show that PACAP increases, in a concentration-dependent manner, burst frequency and decreases burst amplitude of the respiratory rhythm generated in vitro. In conclusion, PACAP is a neuromodulator of the PreB?tC suggesting that alterations in such neuromodulation might be involved in the sudden infant death-like phenotype. |
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Authors:
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Fernando Pe?a |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 669 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 119-22 Citation Subset: IM |
Affiliation:
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Departamento de Farmacobiolog?a, Cinvestav-IPN, M?xico, DF, M?xico. jfpena@cinvestav.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Stem / drug effects*, physiology* Dose-Response Relationship, Drug Mice Neurotransmitter Agents / pharmacology Periodicity* Pituitary Adenylate Cyclase-Activating Polypeptide / pharmacology* Respiratory Mechanics / drug effects*, physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 0/Pituitary Adenylate Cyclase-Activating Polypeptide |
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