Document Detail


PACAP is an Endogenous Protective Factor-Insights from PACAP-Deficient Mice.
MedLine Citation:
PMID:  22528455     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widespread neuropeptide with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP therefore results in a variety of abnormalities. One of the important effects of PACAP is its neuroprotective and general cytoprotective role. PACAP protects neurons and other tissues against ischemic, toxic, and traumatic lesions. Data obtained from PACAP-deficient mice provide evidence that endogenous PACAP also has protective functions. Mice lacking PACAP are more vulnerable to different in vitro and in vivo insults. The present review summarizes data on the increased sensitivity of PACAP-deficient mice against harmful stimuli. Mice lacking PACAP respond with a higher degree of injury in cerebral ischemia, autoimmune encephalomyelitis, and axonal lesion. Retinal ischemic and excitotoxic injuries also produce increased cell loss in PACAP-deficient mice. In peripheral organs, kidney cell cultures from PACAP-deficient mice are more sensitive to oxidative stress and in vitro hypoxia. In vivo, PACAP-deficient mice have a negative histological outcome and altered cytokine response in kidney and small intestine ischemia/reperfusion injury. Large intestinal inflammation, toxic lesion of the pancreas, and doxorubicin-induced cardiomyopathy are also more severe with a lack of endogenous PACAP. Finally, an increased inflammatory response has been described in subacute endotoxin-induced airway inflammation and in an oxazolone-induced allergic contact dermatitis model. In summary, lack of endogenous PACAP leads to higher vulnerability in a number of injuries in the nervous system and peripheral organs, supporting the hypothesis that PACAP is part of the endogenous cytoprotective machinery.
Authors:
D Reglodi; P Kiss; K Szabadfi; T Atlasz; R Gabriel; G Horvath; P Szakaly; B Sandor; A Lubics; E Laszlo; J Farkas; A Matkovits; R Brubel; H Hashimoto; A Ferencz; A Vincze; Z Helyes; L Welke; A Lakatos; A Tamas
Related Documents :
10436655 - Influence of dietary protein content on trypanosoma cruzi infection in germfree and con...
22713745 - Animal models to study the pathogenesis of enterotoxigenic clostridium perfringens infe...
8300235 - Immunization against experimental coccidiosis produces contrasting results in inbred mi...
19706905 - Immunolocalization and challenge studies using a recombinant vibrio cholerae ghost expr...
21889885 - Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via...
7622505 - The receptor for urokinase-type plasminogen activator is not essential for mouse develo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-14
Journal Detail:
Title:  Journal of molecular neuroscience : MN     Volume:  -     ISSN:  1559-1166     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002991     Medline TA:  J Mol Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anatomy, PTE-MTA "Lendulet" PACAP Research Group, University of Pecs, 7624, Pecs, Szigeti u 12, Hungary, dora.reglodi@aok.pte.hu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  MicroRNA-21 Inhibitor Sensitizes Human Glioblastoma U251 Stem Cells to Chemotherapeutic Drug Temozol...
Next Document:  Pretreatment with nonselective cationic channel inhibitors blunts the PACAP-induced increase in guin...