Document Detail

The PABA story.
MedLine Citation:
PMID:  10098293     Owner:  NLM     Status:  MEDLINE    
The qualities of para-aminobenzoic acid (PABA) are discussed and an account is given of how it came to be the favourite sunscreen of the post World War II era. Slowly, however, dermatologists became aware that it was a fairly common sensitizer and that it tended to cross-sensitize with compounds of similar chemical structure both in contact with the skin and given as systemic drugs. Furthermore, continued exposure to chemicals of this type could lead to autoimmune responses especially systemic lupus erythematosus and dermatomyositis. Discussion of these complications from the use of PABA took place at two meetings of the Dermatological Association of Australia in 1964 and 1965, and played a part in the slow withdrawal of PABA from sunscreens.
B S Mackie; L E Mackie
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  40     ISSN:  0004-8380     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-20     Completed Date:  1999-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  51-3     Citation Subset:  IM; Q    
Prince Henry Hospital, Sydney, Australia.
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MeSH Terms
4-Aminobenzoic Acid / adverse effects,  history*
Drug Eruptions / etiology,  history
History, 20th Century
Sunscreening Agents / adverse effects,  history*
Reg. No./Substance:
0/Sunscreening Agents; 150-13-0/4-Aminobenzoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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