| P846, a new gadolinium based low diffusion magnetic resonance contrast agent, in characterizing occlusive infarcts, reperfused ischemic myocardium and reperfused infarcts in rats. | |
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MedLine Citation:
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PMID: 18446394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: This study has two objectives: (1) to compare the kinetics of low diffusion P846 with Gd-DOTA using inversion recovery echo planar (IR-EPI) magnetic resonance (MR) imaging and (2) to determine the potential of P846 in defining myocardial viability in hearts subjected to various injuries using T1-weighted spin echo (T1-SE). MATERIALS AND METHODS: Rats were subjected to (1) occlusive infarcts (n = 16), (2) reperfused ischemic injuries (n = 8) or (3) reperfused infarcts (n = 16). A dose of 0.05 mmol/kg P846 was compared to 0.1 mmol/kg Gd-DOTA. IR-EPI and T1-SE images were obtained during 60 min. T(1), DeltaR(1) and DeltaR(1) ratio were measured on IR-EPI. Infarct extents were evaluated on T1-SE and compared with histochemical staining. RESULTS: Blood DeltaR(1) was higher at 5 min after P846 (6.36 +/- 0.32 s(-1)) than after Gd-DOTA (1.30 +/- 0.14 s(-1); P < 0.001). With P846, occlusive infarcts appeared as a hypoenhanced region surrounded by a hyperenhanced rim that lasted for 60 min. The increase in the DeltaR(1) ratio value was slower after P846 than with Gd-DOTA in the reperfused infarcts, suggesting low diffusion/convection of P846. Gd-DOTA homogenously enhanced both occlusive and reperfused infarcts at 30 min. CONCLUSION: P846 provides better contrast and extended discrimination between occlusive and reperfused infarcts compared with Gd-DOTA. The gadolinium dose could be reduced with P846. |
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Authors:
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Alexis Jacquier; Matthew Bucknor; Loi Do; Philippe Robert; Claire Corot; Charles B Higgins; Maythem Saeed |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-30 |
Journal Detail:
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Title: Magma (New York, N.Y.) Volume: 21 ISSN: 0968-5243 ISO Abbreviation: MAGMA Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-06-13 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310752 Medline TA: MAGMA Country: Germany |
Other Details:
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Languages: eng Pagination: 207-18 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of California San Francisco, 513 Parnassus Ave, HSW 207B, San Francisco, CA 94134-0628, USA. alexis.jacquier@ap-hm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / diagnosis* Contrast Media* Echo-Planar Imaging / methods Gadolinium DTPA / diagnostic use Myocardial Infarction / diagnosis* Myocardial Reperfusion* Organometallic Compounds / diagnostic use* Rats |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/P846 compound; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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