| P75 neurotrophin receptor is a regulatory factor in sudden cardiac death with myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 22704942 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Sudden cardiac death (SCD) is a major cause of morbidity and mortality in patients with coronary artery diseases and myocardial infarction (MI). Sympathetic stimulation and sympathetic neural remodeling are important in the generation of SCD in diseased heart. The balance of nerve growth factor (NGF) and semaphoring 3A determines the sympathetic innervation patterning. Recently studies showed that P75 neurotrophin receptor (P75 NTR) is the main receptor for NGF mediates sympathetic hyperinnervation in the heart, and also interacts with semaphoring 3A. Sympathetic axons lacking P75 NTR are more sensitive to semaphoring 3A in vitro than control neurons, resulting in decreased sympathetic innervation in the left ventricular subendocardium. P75 NTR(-/-) mice had increased sympathetic heterogeneity and more spontaneous ventricular arrhythmias. Based on current studies, we present a hypothesis that P75 NTR plays an important regulatory role in sudden cardiac after myocardial infarction and hope to find new therapeutic target for SCD. |
| | |
Authors:
|
Ming-Jie Yuan; He Huang; Cong-Xin Huang |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-15 |
Journal Detail:
|
Title: Medical hypotheses Volume: - ISSN: 1532-2777 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
|
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Working with our smoker patients in primary care. Analysis of cost-effectiveness.
Next Document: Hygiene hypothesis: Why south/north geographical differences in prevalence of asthma and sarcoidosis...