| p53 Pro-Oxidant Activity in the Central Nervous System: Implication in Aging and Neurodegenerative Diseases. | |
| | |
MedLine Citation:
|
PMID: 20849375 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract Recent advances in delineating the biological functions of p53 had shed the light on its key role in the multifacets of cellular homeostasis. After its activation, via DNA damage, oxidative stress, or aberrant expression of oncogenes, p53 transduces its classical effect through several mechanisms comprising activation of the DNA repair machinery, cell cycle arrest, and initiation of apoptosis or senescence. In the mammalian brain, p53 plays critical functions in normal development, tumor suppression, neurodegenerative diseases, and aging. Herein, we focus on the constitutive pro-oxidant activity of p53 in neurons and discuss the potential implication of this finding in the context of neurodegenerative diseases and normal brain aging. Antioxid. Redox Signal. 15, 1729-1737. |
| | |
Authors:
|
Wassim Chatoo; Mohamed Abdouh; Gilbert Bernier |
Related Documents
:
|
15322115 - Protein kinase cdelta regulates apoptosis via activation of stat1. 12506145 - P53 mediates the apoptotic response to gtp depletion after renal ischemia-reperfusion: ... 11034215 - Role for the p53 homologue p73 in e2f-1-induced apoptosis. 20587415 - The calcium-binding protein s100b down-regulates p53 and apoptosis in malignant melanoma. 22239975 - Lps induced inflammatory responses in human peripheral blood mononuclear cells is media... 19429345 - Matrine induces apoptosis in gastric carcinoma cells via alteration of fas/fasl and act... |
Publication Detail:
|
Type: Journal Article Date: 2011-03-31 |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 15 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 1729-37 Citation Subset: IM |
Affiliation:
|
1 Developmental Biology Laboratory, Maisonneuve-Rosemont Hospital , Montréal, Canada . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: How proteins form disulfide bonds.
Next Document: Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons.