Document Detail

P53 deletion is not a frequent event in multiple myeloma.
MedLine Citation:
PMID:  10468863     Owner:  NLM     Status:  MEDLINE    
Recently a high incidence of interstitial deletion of the P53 locus has been reported in multiple myeloma (MM) patients. Considering the importance of such an event, we analysed 79 patients with advanced-stage disease using fluorescence in situ hybridization (FISH). Strikingly, we found only 7/79 patients with a P53 deletion. In order to rule out any differences in probe selection, we reanalysed all the patients with the same probe as that used in a previous study, and confirmed the low incidence of P53 deletion (7/79, 9%). The only explanation is a difference in hybridization efficiency. Since hybridization is far less efficient on malignant plasma cells than on other bone marrow cells we suggest that this poor hybridization efficiency may lead to a false P53 deletion.
H Avet-Loiseau; J Y Li; C Godon; N Morineau; A Daviet; J L Harousseau; T Facon; R Bataille
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  106     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  717-9     Citation Subset:  IM    
Laboratory of Haematology, University Hospital, Lille, France.
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MeSH Terms
Gene Deletion*
Genes, p53 / genetics*
In Situ Hybridization, Fluorescence
Multiple Myeloma / genetics*
Comment In:
Br J Haematol. 2000 Mar;108(4):886   [PMID:  10792302 ]

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