| P53 deletion is not a frequent event in multiple myeloma. | |
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MedLine Citation:
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PMID: 10468863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently a high incidence of interstitial deletion of the P53 locus has been reported in multiple myeloma (MM) patients. Considering the importance of such an event, we analysed 79 patients with advanced-stage disease using fluorescence in situ hybridization (FISH). Strikingly, we found only 7/79 patients with a P53 deletion. In order to rule out any differences in probe selection, we reanalysed all the patients with the same probe as that used in a previous study, and confirmed the low incidence of P53 deletion (7/79, 9%). The only explanation is a difference in hybridization efficiency. Since hybridization is far less efficient on malignant plasma cells than on other bone marrow cells we suggest that this poor hybridization efficiency may lead to a false P53 deletion. |
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Authors:
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H Avet-Loiseau; J Y Li; C Godon; N Morineau; A Daviet; J L Harousseau; T Facon; R Bataille |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of haematology Volume: 106 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-26 Completed Date: 1999-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 717-9 Citation Subset: IM |
Affiliation:
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Laboratory of Haematology, University Hospital, Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Gene Deletion* Genes, p53 / genetics* Humans In Situ Hybridization, Fluorescence Multiple Myeloma / genetics* |
| Comments/Corrections | |
Comment In:
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Br J Haematol. 2000 Mar;108(4):886
[PMID:
10792302
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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