Document Detail


P53 deletion is not a frequent event in multiple myeloma.
MedLine Citation:
PMID:  10468863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently a high incidence of interstitial deletion of the P53 locus has been reported in multiple myeloma (MM) patients. Considering the importance of such an event, we analysed 79 patients with advanced-stage disease using fluorescence in situ hybridization (FISH). Strikingly, we found only 7/79 patients with a P53 deletion. In order to rule out any differences in probe selection, we reanalysed all the patients with the same probe as that used in a previous study, and confirmed the low incidence of P53 deletion (7/79, 9%). The only explanation is a difference in hybridization efficiency. Since hybridization is far less efficient on malignant plasma cells than on other bone marrow cells we suggest that this poor hybridization efficiency may lead to a false P53 deletion.
Authors:
H Avet-Loiseau; J Y Li; C Godon; N Morineau; A Daviet; J L Harousseau; T Facon; R Bataille
Related Documents :
8719743 - Deficiency of merosin (laminin m or alpha 2) in congenital muscular dystrophy associate...
9440803 - Early-onset facioscapulohumeral muscular dystrophy: two case reports.
18493393 - New strategies for treating myomas.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  106     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  717-9     Citation Subset:  IM    
Affiliation:
Laboratory of Haematology, University Hospital, Lille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Gene Deletion*
Genes, p53 / genetics*
Humans
In Situ Hybridization, Fluorescence
Multiple Myeloma / genetics*
Comments/Corrections
Comment In:
Br J Haematol. 2000 Mar;108(4):886   [PMID:  10792302 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblast...
Next Document:  Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous...