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P53 deletion is independently associated with increased age and decreased survival in a cohort of Chinese patients with diffuse large B-cell lymphoma.
MedLine Citation:
PMID:  22545859     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract To compare the cytogenetic profile and survivalb.etween elderly and non-elderly Chinese patients with diffuse large B-cell lymphoma (DLBCL). We identified 50 patients with DLBCL and divided them by age into elderly (≥60 years) and non-elderly (<60 years) groups. We detected deletion in P53 or translocations in Bcl-2, Bcl-6, or c-myc genes by fluorescence in situ hybridization (FISH). P53 deletion is significantly more common in elderly versus non-elderly patients (62% vs. 17%, respectively, P=0.001) There were no significant differences in the rates of Bcl-2, Bcl-6, or c-myc gene rearrangements between elderly and non-elderly patients (P>0.25 for each). Median survival was significantly longer in non-elderly compared to elderly patients. P53 deletion was an independent prognostic factor of decreased survival in DLBCL patients independent of age. P53 deletion as detected by FISH is associated with both increased age and decreased survival in Chinese patients with DLBCL. This association with decreased survival is at least partly independent of age. P53 deletion could serve as a prognostic factor in DLBCL independent of or in combination with age.
Authors:
Jia Zhuxia; He Jinyuan; Cen Ling; Han Wenmin; Jiang Naike; Yang Jianhe; Zhou Min
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-30
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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