Document Detail

P50 values in hypoxic albino rats of first and second generation.
MedLine Citation:
PMID:  1841514     Owner:  NLM     Status:  MEDLINE    
We determined the "in vivo" (arterial pH and PCO2) and standard (pH = 7.4, PCO2 = 40 mm Hg) PO2 at 50% O2 saturation of hemoglobin (P50, vv and P50, st) in Wistar albino rats when living in a normobaric hypoxic environment. Two generations of hypoxic rats were observed for changes in their P50, vv, P50, st, (n50) 2,3-diphosphoglycerate (2,3-DPG), hemoglobin (Hb) and DPG-Hb ratio: the first generation (H1) and the second generation (H2). A few hours after birth, the H1 rats were placed and raised in a normobaric hypoxic environment (10% O2 in N2). The H2 rats were born from hypoxic parents of first generation and were raised in the same hypoxic environment. The control group had a normoxic environment. The P50, st was significantly higher in H1 rats than both H2 and controls. P50, st was similar in H2 and control rats. The P50, vv was significantly higher in H1 rats than both H2 and controls but it was significantly lower in H2 when compared with both controls and H1. Hb and 2,3-DPG had values significantly greater for both H1 and H2 when compared with their controls. However, the values of H2 were significantly lower than H1. The effectiveness of an increase in Hb-O2 affinity as an adaptive mechanism in H2 rats is discussed.
U Quatrini; A Licciardi; G Morici
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  78     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  1991  
Date Detail:
Created Date:  1992-11-05     Completed Date:  1992-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
Istituto di Fisiologia Umana, Universita Degli Studi, Palermo, Italy.
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MeSH Terms
Anoxia / blood*
Diphosphoglyceric Acids / metabolism
Hydrogen-Ion Concentration
Oxygen / blood*
Oxyhemoglobins / metabolism
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Oxyhemoglobins; 138-81-8/2,3-Diphosphoglycerate; 7782-44-7/Oxygen

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