| P50 suppression, prepulse inhibition, and startle reactivity in the same patient cohort suffering from posttraumatic stress disorder. | |
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MedLine Citation:
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PMID: 20347156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Psychophysiological alterations like impaired gating and increased startle have been reported in patients with posttraumatic stress disorder (PTSD). However, findings are inconsistent, and potential relationships to symptomatology remain unclear. AIMS: The present study investigates two distinct operational measures of gating and startle reactivity within the same patients suffering from PTSD and their relationship to PTSD symptomatology. METHODS: Prepulse inhibition of the acoustic evoked startle reflex, P50 suppression of auditory event related potentials, and startle reactivity were assessed in three distinct experiments in 27 PTSD patients and compared to 25 healthy control subjects. RESULTS: PTSD patients exhibited impaired P50 suppression and exaggerated startle. Lower P50 suppression was associated with higher levels of general psychopathology. Patients and control subjects did not differ in PPI. LIMITATIONS: Some of the limitations include, that the control group compromised of non-trauma exposure subjects and menstrual cycle in female participants potentially affecting PPI was not controlled. CONCLUSIONS: Deficient P50 gating, not related to specific trauma or distinct symptom clusters reflects a robust finding in PTSD patients. In contrast, further research is needed to clarify whether PPI is affected in PTSD. |
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Authors:
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Dominique H Holstein; Franz X Vollenweider; Lutz Jäncke; Christian Schopper; Philipp A Csomor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-26 |
Journal Detail:
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Title: Journal of affective disorders Volume: 126 ISSN: 1573-2517 ISO Abbreviation: J Affect Disord Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 188-97 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Psychiatric University Hospital Zürich, Zürich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Case-Control Studies Electroencephalography Electromyography Evoked Potentials, Auditory / physiology* Female Humans Male Psychiatric Status Rating Scales Psychometrics Sensory Gating / physiology* Startle Reaction / physiology* Stress Disorders, Post-Traumatic / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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