Document Detail

P50 suppression, prepulse inhibition, and startle reactivity in the same patient cohort suffering from posttraumatic stress disorder.
MedLine Citation:
PMID:  20347156     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Psychophysiological alterations like impaired gating and increased startle have been reported in patients with posttraumatic stress disorder (PTSD). However, findings are inconsistent, and potential relationships to symptomatology remain unclear.
AIMS: The present study investigates two distinct operational measures of gating and startle reactivity within the same patients suffering from PTSD and their relationship to PTSD symptomatology.
METHODS: Prepulse inhibition of the acoustic evoked startle reflex, P50 suppression of auditory event related potentials, and startle reactivity were assessed in three distinct experiments in 27 PTSD patients and compared to 25 healthy control subjects.
RESULTS: PTSD patients exhibited impaired P50 suppression and exaggerated startle. Lower P50 suppression was associated with higher levels of general psychopathology. Patients and control subjects did not differ in PPI.
LIMITATIONS: Some of the limitations include, that the control group compromised of non-trauma exposure subjects and menstrual cycle in female participants potentially affecting PPI was not controlled.
CONCLUSIONS: Deficient P50 gating, not related to specific trauma or distinct symptom clusters reflects a robust finding in PTSD patients. In contrast, further research is needed to clarify whether PPI is affected in PTSD.
Dominique H Holstein; Franz X Vollenweider; Lutz Jäncke; Christian Schopper; Philipp A Csomor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-26
Journal Detail:
Title:  Journal of affective disorders     Volume:  126     ISSN:  1573-2517     ISO Abbreviation:  J Affect Disord     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  188-97     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Psychiatric University Hospital Zürich, Zürich, Switzerland.
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MeSH Terms
Acoustic Stimulation
Case-Control Studies
Evoked Potentials, Auditory / physiology*
Psychiatric Status Rating Scales
Sensory Gating / physiology*
Startle Reaction / physiology*
Stress Disorders, Post-Traumatic / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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