Document Detail


The P50 component of the auditory evoked potential and subtypes of schizophrenia.
MedLine Citation:
PMID:  8372162     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decreased amplitude of the P50 component of the averaged evoked potential has been reported in schizophrenic patients. In an attempt to determine the relationship of this decrease to subtype diagnosis, we compared P50 amplitudes in 24 neuroleptic-free schizophrenic patients with paranoid (n = 13) versus nonparanoid (n = 11) subtype diagnoses. Eleven normal subjects and 11 cocaine users served as control groups. The schizophrenic patients were studied again after they had been treated with neuroleptics for 2 weeks. The control groups were studied again at least 2 weeks later. At baseline, the nonparanoid patients had significantly lower P50 amplitudes than did the normal subjects. The paranoid patients did not differ from the normal control subjects. The cocaine users had significantly decreased P50 amplitudes as compared with the normal control subjects. Neuroleptic treatment had no effect on P50 amplitudes in the paranoid patients but normalized amplitudes in the nonparanoid patients. The data suggest that P50 measurements may be useful in identifying subtypes of schizophrenia.
Authors:
N Boutros; G Zouridakis; T Rustin; C Peabody; D Warner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry research     Volume:  47     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  243-54     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Ohio State University, Columbus 43210-1228.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adolescent
Adult
Attention / drug effects,  physiology
Cerebral Cortex / physiopathology
Cocaine
Evoked Potentials, Auditory / drug effects,  physiology*
Female
Humans
Male
Reaction Time / drug effects,  physiology
Reference Values
Schizophrenia / classification,  physiopathology*
Schizophrenia, Paranoid / classification,  physiopathology,  psychology
Schizophrenic Psychology*
Substance-Related Disorders / physiopathology,  psychology
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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