Document Detail

P300 in Behcet's patients without neurological manifestations.
MedLine Citation:
PMID:  11252299     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Behcet's disease is the association of recurrent aphthous stomatitis with genital ulceration and eye disease. Neurologic involvement patterns include meningomyelitis, a brain stem syndrome, pyramidal and extrapyramidal abnormality and stroke. In the present study, subclinical involvement was investigated by using P300 in Behcet's patients without neurological manifestation. METHODS: Fifteen patients and 15 healthy volunteers were accepted for the study. P300 from vertex (Cz) electrode sites of the 10-20 system using electrodes and motor response time were recorded. RESULTS: Patients had significantly prolonged latencies of P300 as compared to normal controls (p=0.013) but no significant differences in amplitude (p=1.000). Patients showed a significantly delayed motor response time than controls (p=0.006). Nine patients (60%) had P300 latency and eight patients (53.3%) had motor response time values exceeding the mean of controls by two standard deviations. CONCLUSION: The findings suggest that the P300 measures and motor response time may reflect subclinical neurologic involvement in Behcet's disease.
H Kececi; M Akyol
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  28     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-16     Completed Date:  2001-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Department of Neurology, Medical Faculty of Cumhuriyet University, Sivas, Turkey.
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MeSH Terms
Behcet Syndrome / physiopathology*
Event-Related Potentials, P300 / physiology*
Evoked Potentials, Auditory, Brain Stem / physiology
Evoked Potentials, Motor / physiology
Middle Aged

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