| P3 abnormality in fragile X syndrome. | |
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MedLine Citation:
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PMID: 2949781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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P300 (P3) and other long latency auditory event-related potentials (ERPs) were recorded in 33 adults with fragile X syndrome. All patients had an abnormal P3. It was longer in latency and smaller in amplitude than in controls. In several cases, it was split into two separate components, and in others, was generated in response to expected as well as unexpected events. Abnormal P3 was not related to age, percentage cell fragility, or intellectual ability, but complete splitting was associated with the presence of physical dysmorphisms. Our results are interpreted as showing that in fragile X syndrome there is dysgenesis of the hippocampus and related brain structures. |
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Authors:
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D M St Clair; D H Blackwood; C J Oliver; P Dickens |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological psychiatry Volume: 22 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-04-07 Completed Date: 1987-04-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 303-12 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Down Syndrome / physiopathology Evoked Potentials, Auditory* Female Fragile X Syndrome / physiopathology* Humans Male Middle Aged Reaction Time Sex Chromosome Aberrations / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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