Document Detail


P2X receptors in sensory neurones.
MedLine Citation:
PMID:  10823099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
P2X receptors are a family of ligand-gated ion channels responsive to ATP. Seven subtypes have been identified which form homo-multimeric or hetero-multimeric pores. P2X3 receptors are selectively expressed predominantly on small-diameter nociceptive sensory neurones in the dorsal root, trigeminal and nodose ganglia, particularly the non-peptidergic subpopulations labelled with the lectin IB4. P2X2/3 labelling is also present in inner lamina II of the spinal cord and in sensory nerve projections to skin and viscera, but few receptors are present in skeletal muscle. P2X3 receptors are down-regulated after peripheral nerve injury and their expression can be regulated by glial cell-derived neurotrophic factor. P2X receptor activation of sensory neurones has been demonstrated in in vivo pain models, including the rat hindpaw and knee-joint preparations, as well as in inflammatory models. P2X4 and/or P2X6 receptors in the CNS also seem to be involved in pain pathways. Non-nociceptive P2 receptors on sensory nerves are present in muscle and on sensory endings in the heart and lung that initiate reflex activity involving vagal afferent and efferent nerve fibres. The sources of ATP involved in nociception and non-nociceptive sensory nerve stimulation are discussed as well as a novel hypothesis about purinergic mechanosensory transduction.
Authors:
G Burnstock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  84     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-06     Completed Date:  2000-06-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  476-88     Citation Subset:  IM; S    
Affiliation:
Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Down-Regulation / physiology
Mice
Nerve Growth Factors / physiology
Neurons, Afferent / physiology*
Nociceptors / physiology*
Peripheral Nerves / injuries
Rabbits
Rats
Receptors, Purinergic P2 / classification,  physiology*
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 0/Receptors, Purinergic P2

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