Document Detail

P wave dispersion is prolonged in patients with Wilson's disease.
MedLine Citation:
PMID:  18300353     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the P wave dispersion as a non-invasive marker of intra-atrial conduction disturbances in patients with Wilson's disease. METHODS: We compared Wilsonos disease patients (n = 18) with age matched healthy subjects (n = 15) as controls. The diagnosis was based on clinical symptoms, laboratory tests (ceruloplasmin, urinary and hepatic copper concentrations). P wave dispersion, a measurement of the heterogeneity of atrial depolarization, was measured as the difference between the duration of the longest and the shortest P-waves in 12 lead electrocardiography. RESULTS: All the patients were asymptomatic on cardiological examination and have sinusal rhythm in electrocardiography. Left ventricular and left atrial diameters, left ventricular ejection fraction and left ventricular mass index were similar in both groups. The Wilson's disease patients had a significantly higher P wave dispersion compared with the controls (44.7 +/- 5.8 vs 25.7 +/- 2.5, P < 0.01). CONCLUSION: There was an increase in P wave dispersion in cardiologically asymptomatic Wilson's disease patients which probably represents an early stage of cardiac involvement.
Nurcan Arat; Sabite Kacar; Zehra Golbasi; Meral Akdogan; Yeliz Sokmen; Sedef Kuran; Ramazan Idilman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  14     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-08-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1252-6     Citation Subset:  IM    
Türkiye Yüksek Ihtisas Hospital, Clinic of Cardiology, Sihhiye 06100, Ankara, Turkey.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis
Atrial Fibrillation / pathology
Case-Control Studies
Echocardiography / methods
Electrocardiography / methods*
Heart Atria / pathology
Hepatolenticular Degeneration / therapy*
Liver / pathology
Middle Aged

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