Document Detail

P wave dispersion in familial Mediterranean fever.
MedLine Citation:
PMID:  20496067     Owner:  NLM     Status:  In-Data-Review    
Familial Mediterranean fever (FMF) is a hereditary disease characterized by recurrent and self-terminated attacks of fever and polyserositis. A recent study found that FMF patients had an abnormally high P wave duration and P wave dispersion, markers for supraventricular arrhythmogenicity. The aim of our study was to further evaluate atrial dispersion in FMF patients. The study group consisted of 26 patients with uncomplicated FMF and age- and sex-matched control subjects. All participants underwent 12-lead electrocardiography under strict standards. P wave length and P wave dispersion were computed from a randomly selected beat and from an averaged beat constructed from 7 to 12 beats, included in a 10-s ECG. No statistically significant differences were found between the groups in minimal, maximal, and average P wave duration and P wave dispersion calculated either from a random beat or averaged beats. During 6 months of follow-up, no supraventricular arrhythmias were documented in either group. FMF patients who are continuously treated with colchicine and do not develop amyloidosis have normal atrial conduction parameters and therefore seemingly do not have an increased electrocardiographic risk of atrial fibrillation.
Naomi Nussinovitch; Avi Livneh; Keren Katz; Moshe Nussinovitch; Benjamin Volovitz; Merav Lidar; Udi Nussinovitch
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Publication Detail:
Type:  Journal Article     Date:  2010-05-23
Journal Detail:
Title:  Rheumatology international     Volume:  31     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1591-4     Citation Subset:  IM    
Hypertension Unit and Department of Internal Medicine D, Sheba Medical Center, Tel Hashomer, Israel,
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