Document Detail


P-glycoprotein-mediated multidrug resistance and cytotoxic effector cells.
MedLine Citation:
PMID:  1358293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. MDR is a complex and multifactorial phenomenon. One important and common mechanism used by cancer cells as a defense against cytotoxic drugs is a 170-kD plasma membrane glycoprotein, P-glycoprotein (P-gp). P-gp confers resistance by actively pumping cytotoxic drugs out of cancer cells. Paradoxically, P-gp overexpression on tumor cells is frequently associated with enhanced susceptibility to lymphokine-activated killer cell activity. This enhanced susceptibility is not observed with P-gp- MDR cells, nor is susceptibility to natural killer cells increased. The physiologic, evolutionary and immunologic concepts with regard to the P-gp and the possible intervention of the function of the P-gp in cancer therapy are reviewed.
Authors:
B Savas; S P Cole; T F Akoglu; H F Pross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Natural immunity     Volume:  11     ISSN:  1018-8916     ISO Abbreviation:  Nat. Immun.     Publication Date:    1992 Jul-Aug
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206126     Medline TA:  Nat Immun     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  177-92     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Queen's University, Kingston, Canada.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Drug Resistance / immunology
Humans
Killer Cells, Lymphokine-Activated / immunology*
Killer Cells, Natural / immunology*
Membrane Glycoproteins / genetics,  physiology*
Neoplasm Proteins / genetics,  physiology*
Neoplasms / drug therapy
P-Glycoprotein
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/P-Glycoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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