Document Detail

P-glycoprotein-mediated multidrug resistance and cytotoxic effector cells.
MedLine Citation:
PMID:  1358293     Owner:  NLM     Status:  MEDLINE    
Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. MDR is a complex and multifactorial phenomenon. One important and common mechanism used by cancer cells as a defense against cytotoxic drugs is a 170-kD plasma membrane glycoprotein, P-glycoprotein (P-gp). P-gp confers resistance by actively pumping cytotoxic drugs out of cancer cells. Paradoxically, P-gp overexpression on tumor cells is frequently associated with enhanced susceptibility to lymphokine-activated killer cell activity. This enhanced susceptibility is not observed with P-gp- MDR cells, nor is susceptibility to natural killer cells increased. The physiologic, evolutionary and immunologic concepts with regard to the P-gp and the possible intervention of the function of the P-gp in cancer therapy are reviewed.
B Savas; S P Cole; T F Akoglu; H F Pross
Related Documents :
10925353 - Intracellular p-glycoprotein expression is associated with the intrinsic multidrug resi...
7743893 - Is reduced accumulation of hoechst 33342 in multidrug resistant cells related to p-glyc...
12911753 - A novel method of generating neuronal cell lines from gene-knockout mice to study prion...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Natural immunity     Volume:  11     ISSN:  1018-8916     ISO Abbreviation:  Nat. Immun.     Publication Date:    1992 Jul-Aug
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206126     Medline TA:  Nat Immun     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  177-92     Citation Subset:  IM    
Department of Microbiology and Immunology, Queen's University, Kingston, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / pharmacology*
Drug Resistance / immunology
Killer Cells, Lymphokine-Activated / immunology*
Killer Cells, Natural / immunology*
Membrane Glycoproteins / genetics,  physiology*
Neoplasm Proteins / genetics,  physiology*
Neoplasms / drug therapy
Reg. No./Substance:
0/Antineoplastic Agents; 0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/P-Glycoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gastric emptying after pancreatoduodenectomy with total stomach preservation and selective proximal ...
Next Document:  The transport of neurotransmitters into synaptic vesicles.