| P-glycoprotein-mediated multidrug resistance and cytotoxic effector cells. | |
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MedLine Citation:
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PMID: 1358293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. MDR is a complex and multifactorial phenomenon. One important and common mechanism used by cancer cells as a defense against cytotoxic drugs is a 170-kD plasma membrane glycoprotein, P-glycoprotein (P-gp). P-gp confers resistance by actively pumping cytotoxic drugs out of cancer cells. Paradoxically, P-gp overexpression on tumor cells is frequently associated with enhanced susceptibility to lymphokine-activated killer cell activity. This enhanced susceptibility is not observed with P-gp- MDR cells, nor is susceptibility to natural killer cells increased. The physiologic, evolutionary and immunologic concepts with regard to the P-gp and the possible intervention of the function of the P-gp in cancer therapy are reviewed. |
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Authors:
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B Savas; S P Cole; T F Akoglu; H F Pross |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Natural immunity Volume: 11 ISSN: 1018-8916 ISO Abbreviation: Nat. Immun. Publication Date: 1992 Jul-Aug |
Date Detail:
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Created Date: 1992-12-04 Completed Date: 1992-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206126 Medline TA: Nat Immun Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 177-92 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Queen's University, Kingston, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Drug Resistance / immunology Humans Killer Cells, Lymphokine-Activated / immunology* Killer Cells, Natural / immunology* Membrane Glycoproteins / genetics, physiology* Neoplasm Proteins / genetics, physiology* Neoplasms / drug therapy P-Glycoprotein |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/P-Glycoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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