Document Detail


P-cadherin expression in feline mammary tissues.
MedLine Citation:
PMID:  23091776     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of normal (n = 4), hyperplastic (n = 12), and neoplastic (n = 45) feline mammary tissues were examined. In both normal and hyperplastic mammary tissues as well as in benign tumours, P-cadherin immunolabelling was restricted to myoepithelial cells. In malignant tumours, however, there was an aberrant epithelial P-cadherin immunoexpression in 64.1% (n = 25) of cases, with a membranous and/or cytoplasmic pattern of distribution. A statistically significant relationship was seen between epithelial P-cadherin expression and malignant mammary lesions (P = 0.0001). In malignant mammary tumours, there was likewise a statistically significant relationship between aberrant P-cadherin immunoexpression and histological grade (P = 0.0132). Aberrant epithelial P-cadherin expression seems to be related to malignancy in the feline mammary gland. To confirm the results of this investigation, further studies with larger samples and follow-up studies are warranted.
Authors:
Ana Catarina Figueira; Ana Sofia Teodósio; Júlio Carvalheira; Manuela Lacerda; Augusto de Matos; Fátima Gärtner
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Publication Detail:
Type:  Journal Article     Date:  2012-10-03
Journal Detail:
Title:  Veterinary medicine international     Volume:  2012     ISSN:  2042-0048     ISO Abbreviation:  Vet Med Int     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-23     Completed Date:  2012-10-24     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101524203     Medline TA:  Vet Med Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687424     Citation Subset:  -    
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