Document Detail

P-wave indices, distribution and quality control assessment (from the Framingham Heart Study).
MedLine Citation:
PMID:  20146786     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: P-wave indices of maximum P-wave duration and P-wave dispersion have been examined in a broad array of cardiovascular and noncardiovascular disease states. The P-wave indices literature has been highly heterogeneous in measurement methodologies, described quality control metrics, and distribution of values. We therefore sought to determine the reproducibility of P-wave indices in a community-based cohort.
METHODS: P-wave indices were measured in sequential subjects enrolled in the Framingham Heart Study. Electrocardiograms were obtained at the 11th biennial visit of the Original Cohort (n = 250) and the initial visit of the Offspring Cohort (n = 252). We determined the mean P-wave durations, interlead correlations, and P-wave indices. We then chose 20 ECGs, 10 from each cohort, and assessed intrarater and interrater variability.
RESULTS: The maximum P-wave duration ranged from 71 to 162 ms with mean of 112 + or - 12 ms. The minimum P-wave duration ranged from 35 to 103 ms with mean of 65 + or - 10 ms. P-wave dispersion ranged from 12 to 82 ms. The mean P-wave dispersion was 48 + or - 12 ms (40-56). The intrarater intraclass correlation coefficient (ICC) was r = 0.80 for maximum P-wave duration and r = 0.82 for P-wave dispersion. The interrater ICC was 0.56 for maximum P-wave duration and 0.70 for P-wave dispersion.
CONCLUSIONS: We demonstrated excellent intrarater reproducibility and fair interrater reproducibility for calculating P-wave indices. Reproducibility is frequently lacking in studies of P-wave indices, but is an essential component for the field's growth and epidemiologic contribution.
Jared W Magnani; Michael J Mazzini; Lisa M Sullivan; MaryAnn Williamson; Patrick T Ellinor; Emelia J Benjamin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  15     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-11     Completed Date:  2010-05-27     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
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MeSH Terms
Cohort Studies
Coronary Disease / epidemiology
Cross-Sectional Studies
Electrocardiography / methods*,  statistics & numerical data*
Massachusetts / epidemiology
Middle Aged
Observer Variation
Prospective Studies
Quality Control*
Quality of Health Care / statistics & numerical data*
Reproducibility of Results
Risk Factors
Time Factors
Grant Support
K24 HL105780/HL/NHLBI NIH HHS; L30 HL097675/HL/NHLBI NIH HHS; L30 HL097675-01/HL/NHLBI NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; R01 AG028321/AG/NIA NIH HHS; R01 AG028321-04/AG/NIA NIH HHS; R01 HL092577/HL/NHLBI NIH HHS; R01 HL092577-01A1/HL/NHLBI NIH HHS; R01 HL104156/HL/NHLBI NIH HHS

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