| P-wave indices: derivation of reference values from the Framingham Heart Study. | |
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MedLine Citation:
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PMID: 20946557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: P-wave indices, an electrocardiographic phenotype reflecting atrial electrophysiology and morphology, may be altered in multiple disease states or by cardiovascular risk factors. Reference values for P-wave indices, providing cut points for their classification and interpretation, have not yet been established and are essential toward facilitating clinical application and comparison between studies. METHODS: We randomly selected 20 men and 20 women from 10-year age intervals between <25 years to 76-85 years from the Framingham Heart Study Original and Offspring Cohorts, excluding subjects with prevalent cardiovascular disease, hypertension, diabetes or obesity. The total included 295 subjects; eligibility in women >75 years was limited by exclusion criteria. We used a digital measurement technique with demonstrated intrarater reproducibility to determine P-wave indices. P-wave indices examined included the maximum, mean, lead II and PR durations, dispersion, and the standard deviation of duration. RESULTS: All P-wave indices were significantly (P < 0.0001) correlated with advancing age. Means of all P-wave indices were lower in women as compared to men. PR-interval duration was strongly correlated with maximum, mean, and lead II mean P-wave durations. In multivariable models adjusting for significant anthropometric and clinical associations risk factors, significant differences persisted by age and sex in P-wave indices. CONCLUSIONS: In our healthy sample without cardiovascular disease, hypertension, diabetes, or obesity, men and older subjects had longer mean P-wave indices. Our description of P-wave indices establishes reference values for future comparative studies and facilitates the classification of P-wave indices. |
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Authors:
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Jared W Magnani; Victor M Johnson; Lisa M Sullivan; Steven A Lubitz; Renate B Schnabel; Patrick T Ellinor; Emelia J Benjamin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 15 ISSN: 1542-474X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2011-02-11 Revised Date: 2013-03-07 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 344-52 Citation Subset: IM |
Copyright Information:
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©2010, Wiley Periodicals, Inc. |
Affiliation:
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Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Aged Aged, 80 and over Cardiovascular Diseases / epidemiology Cohort Studies Electrocardiography / methods*, statistics & numerical data* Female Humans Male Massachusetts / epidemiology Middle Aged Prospective Studies Reference Values Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL092577/HL/NHLBI NIH HHS; K24 HL105780/HL/NHLBI NIH HHS; L30 HL097675/HL/NHLBI NIH HHS; R01 HL092577/HL/NHLBI NIH HHS; R01 HL104156/HL/NHLBI NIH HHS; R21 DA027021/DA/NIDA NIH HHS; RC1 HL101056/HL/NHLBI NIH HHS; RC1 HL101056/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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