Document Detail


P-wave indices: derivation of reference values from the Framingham Heart Study.
MedLine Citation:
PMID:  20946557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: P-wave indices, an electrocardiographic phenotype reflecting atrial electrophysiology and morphology, may be altered in multiple disease states or by cardiovascular risk factors. Reference values for P-wave indices, providing cut points for their classification and interpretation, have not yet been established and are essential toward facilitating clinical application and comparison between studies.
METHODS: We randomly selected 20 men and 20 women from 10-year age intervals between <25 years to 76-85 years from the Framingham Heart Study Original and Offspring Cohorts, excluding subjects with prevalent cardiovascular disease, hypertension, diabetes or obesity. The total included 295 subjects; eligibility in women >75 years was limited by exclusion criteria. We used a digital measurement technique with demonstrated intrarater reproducibility to determine P-wave indices. P-wave indices examined included the maximum, mean, lead II and PR durations, dispersion, and the standard deviation of duration.
RESULTS: All P-wave indices were significantly (P < 0.0001) correlated with advancing age. Means of all P-wave indices were lower in women as compared to men. PR-interval duration was strongly correlated with maximum, mean, and lead II mean P-wave durations. In multivariable models adjusting for significant anthropometric and clinical associations risk factors, significant differences persisted by age and sex in P-wave indices.
CONCLUSIONS: In our healthy sample without cardiovascular disease, hypertension, diabetes, or obesity, men and older subjects had longer mean P-wave indices. Our description of P-wave indices establishes reference values for future comparative studies and facilitates the classification of P-wave indices.
Authors:
Jared W Magnani; Victor M Johnson; Lisa M Sullivan; Steven A Lubitz; Renate B Schnabel; Patrick T Ellinor; Emelia J Benjamin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  15     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-02-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-52     Citation Subset:  IM    
Copyright Information:
©2010, Wiley Periodicals, Inc.
Affiliation:
Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Aged
Aged, 80 and over
Cardiovascular Diseases / epidemiology
Cohort Studies
Electrocardiography / methods*,  statistics & numerical data*
Female
Humans
Male
Massachusetts / epidemiology
Middle Aged
Prospective Studies
Reference Values
Young Adult
Grant Support
ID/Acronym/Agency:
HL092577/HL/NHLBI NIH HHS; K24 HL105780/HL/NHLBI NIH HHS; L30 HL097675/HL/NHLBI NIH HHS; R01 HL092577/HL/NHLBI NIH HHS; R01 HL104156/HL/NHLBI NIH HHS; R21 DA027021/DA/NIDA NIH HHS; RC1 HL101056/HL/NHLBI NIH HHS; RC1 HL101056/HL/NHLBI NIH HHS
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