Document Detail


P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury.
MedLine Citation:
PMID:  10415396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.
Authors:
S G Soriano; Y F Wang; D D Wagner; P S Frenette
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  835     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-28     Completed Date:  1999-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  360-4     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
Affiliation:
Department of Anesthesia, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. soriano@a1.tch.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Infarction / genetics,  pathology
E-Selectin / genetics*
Genetic Engineering
Genetic Predisposition to Disease
Ischemic Attack, Transient / genetics*,  pathology
Mice
Mice, Transgenic
Necrosis
P-Selectin / genetics*
Reperfusion Injury / genetics*,  pathology
Chemical
Reg. No./Substance:
0/E-Selectin; 0/P-Selectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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