Document Detail


Ozone gas effectively kills laboratory strains of Trichophyton rubrum and Trichophyton mentagrophytes using an in vitro test system.
MedLine Citation:
PMID:  22827529     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Ozone gas possesses antimicrobial potential against many microorganisms, however limited data exists on it's effect on the keratinophilic dermatophyte fungi Trichophyton rubrum and Trichophyton mentagrophytes; two organisms commonly isolated as the etiological agent in onychomycosis and tinea pedis patients. Objective/Methods: We utilized a commercial ozone gas generation device (Sani Sport®) for testing the fungicidal effects of ozone on ATCC strains of Trichophyton rubrum and Trichophyton mentagrophytes. Results: We demonstrated that ozone gas is effective in killing > 99% of viable fungi present in various experimental systems. Conclusion: This work represents a proof of principle regarding ozone gas and its' fungicidal effect on dermatophyte fungi. From these findings, further ozone gas studies will be conducted to develop a novel adjunct therapy for use in parallel with current antifungal medications and/or devices to better treat onychomycosis and tinea pedis patients in the short and long term.
Authors:
K Gupta Aditya; Brintnell William
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
645 Windermere Road London, ON, N5X 2P1 , Canada.
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