Document Detail

Oxytocin and vasopressin in the rat do not readily pass from the mother to the amniotic fluid in late pregnancy.
MedLine Citation:
PMID:  3980926     Owner:  NLM     Status:  MEDLINE    
In order to see whether the mother contributes to the vasopressin or oxytocin levels of amniotic fluid, these peptides were measured under conditions (1) in which the fetus lacks vasopressin (Brattleboro strain) and (2) where high maternal oxytocin and vasopressin plasma levels were induced by means of a controlled-delivery Accurel-collodion device. No vasopressin could be demonstrated in amniotic fluid of vasopressin-deficient fetuses present in a heterozygous (i.e., vasopressin-synthetizing mother). High peptide levels on the maternal side of Wistar rats generally failed to affect the amniotic fluid levels. The increase that was occasionally seen in amniotic vasopressin was probably due to fetal release concomitant with growth retardation. Amniotic vasopressin is derived from the fetus. Since amniotic fluid oxytocin is neither derived from the mother nor from the fetal brain, other fetal sources should be considered.
H P Oosterbaan; D F Swaab; G J Boer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  7     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-05-08     Completed Date:  1985-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / metabolism*
Arginine Vasopressin / blood,  metabolism*
Body Weight
Brain / anatomy & histology,  embryology
Fetus / analysis
Maternal-Fetal Exchange*
Organ Size
Oxytocin / metabolism*
Peptides / metabolism
Placenta / anatomy & histology
Rats, Brattleboro
Rats, Inbred Strains
Reg. No./Substance:
0/Peptides; 113-79-1/Arginine Vasopressin; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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