Document Detail

Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women.
MedLine Citation:
PMID:  1957888     Owner:  NLM     Status:  MEDLINE    
The secretory pattern of oxytocin was determined in blood samples taken at 1-minute intervals for 30 minutes from 32 parturient women. The samples were collected in a manner that minimized degradation by plasma oxytocinase, and a highly specific antibody was used for the radioimmunoassay. The results indicated that oxytocin is secreted in discrete pulses of short duration. The frequency of the pulses was significantly higher during spontaneous labor than before the onset of labor. The mean pulse frequencies per 30 minutes were 1.2 +/- 0.54 before labor, 4.2 +/- 0.45 during the first stage, and 6.7 +/- 0.49 during the second and third stages of labor. The mean pulse durations in these three groups were 1.2 +/- 0.20, 1.9 +/- 0.28, and 2.0 +/- 0.26 minutes, respectively. The amplitude of the pulses was variable with no significant differences between the groups, the majority being around 1.0 microU/ml. The spontaneous pulses were of similar magnitude as those measured in 18 women after intravenous injections of 4 to 16 mU of oxytocin, which doses stimulated uterine contractions. We therefore conclude that the pulses of oxytocin observed at increasing frequency during spontaneous labor are of physiologic significance and provide evidence for the participation of oxytocin in the onset and maintenance of spontaneous labor.
A R Fuchs; R Romero; D Keefe; M Parra; E Oyarzun; E Behnke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  165     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-27     Completed Date:  1991-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1515-23     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Cornell University Medical College, New York, NY 10021.
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MeSH Terms
Analysis of Variance
Cystinyl Aminopeptidase / biosynthesis
Dose-Response Relationship, Drug
Labor Stage, First / metabolism
Labor Stage, Second / metabolism
Labor Stage, Third / metabolism
Labor, Obstetric / metabolism*
Oxytocin / pharmacology,  secretion*
Pregnancy / physiology*
Pregnancy Trimester, Third
Reg. No./Substance:
50-56-6/Oxytocin; EC Aminopeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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