| Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women. | |
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MedLine Citation:
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PMID: 1957888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The secretory pattern of oxytocin was determined in blood samples taken at 1-minute intervals for 30 minutes from 32 parturient women. The samples were collected in a manner that minimized degradation by plasma oxytocinase, and a highly specific antibody was used for the radioimmunoassay. The results indicated that oxytocin is secreted in discrete pulses of short duration. The frequency of the pulses was significantly higher during spontaneous labor than before the onset of labor. The mean pulse frequencies per 30 minutes were 1.2 +/- 0.54 before labor, 4.2 +/- 0.45 during the first stage, and 6.7 +/- 0.49 during the second and third stages of labor. The mean pulse durations in these three groups were 1.2 +/- 0.20, 1.9 +/- 0.28, and 2.0 +/- 0.26 minutes, respectively. The amplitude of the pulses was variable with no significant differences between the groups, the majority being around 1.0 microU/ml. The spontaneous pulses were of similar magnitude as those measured in 18 women after intravenous injections of 4 to 16 mU of oxytocin, which doses stimulated uterine contractions. We therefore conclude that the pulses of oxytocin observed at increasing frequency during spontaneous labor are of physiologic significance and provide evidence for the participation of oxytocin in the onset and maintenance of spontaneous labor. |
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Authors:
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A R Fuchs; R Romero; D Keefe; M Parra; E Oyarzun; E Behnke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 165 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-27 Completed Date: 1991-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1515-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Cornell University Medical College, New York, NY 10021. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Cardiotocography Cystinyl Aminopeptidase / biosynthesis Dose-Response Relationship, Drug Female Humans Labor Stage, First / metabolism Labor Stage, Second / metabolism Labor Stage, Third / metabolism Labor, Obstetric / metabolism* Oxytocin / pharmacology, secretion* Pregnancy / physiology* Pregnancy Trimester, Third Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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50-56-6/Oxytocin; EC 3.4.11.3/Cystinyl Aminopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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