Document Detail

Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin.
MedLine Citation:
PMID:  7315896     Owner:  NLM     Status:  MEDLINE    
In the present study we have investigated the effect of oxytocin on the production of prostaglandins E and F (PGE and PGF) by human decidua, amnion, and myometrium in vitro. We found that oxytocin causes a significant increase in the production of both PGE and PGF in the decidua and in the production of PGE in the amnion. In the myometrium the stimulatory effect of oxytocin on PGF production was small and not statistically significant, and PGE production was not affected at all. On the basis of these results, we propose that oxytocin provides the stimulus for the accelerated prostaglandin production in decidua and fetal membranes at the onset of labor. Since oxytocin levels rise in the fetal circulation at this time, the oxytocin stimulus may be of fetal origin as well as of maternal origin.
A R Fuchs; P Husslein; F Fuchs
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  141     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  694-7     Citation Subset:  AIM; IM    
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MeSH Terms
Decidua / drug effects*,  metabolism
Extraembryonic Membranes / drug effects,  metabolism
Labor, Obstetric
Oxytocin / pharmacology*
Prostaglandins / biosynthesis*
Prostaglandins E / biosynthesis
Prostaglandins F / biosynthesis
Stimulation, Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins E; 0/Prostaglandins F; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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