Document Detail

Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder.
MedLine Citation:
PMID:  23950057     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Borderline personality disorder (BPD) is characterized by interpersonal dysfunction, emotional instability, impulsivity, and risk-taking behavior. Recent research has focused on the role of oxytocin in BPD, with mixed results as regards the processing of social stimuli.
METHODS: In a double-blind randomized placebo-controlled study, 13 BPD patients and 13 controls performed a dot probe task to examine attentional biases to happy and angry faces after intranasal application of oxytocin or placebo. Childhood trauma was examined using the childhood trauma questionnaire.
RESULTS: In the placebo condition, patients with BPD (but not controls) showed an avoidant reaction to angry faces (but not happy faces). The strength of the avoidant reaction correlated with the severity of childhood trauma. This behavioral response (as well as the correlation) was abolished in the oxytocin condition.
CONCLUSIONS: Adult patients with BPD show an avoidant response to social threat, a reaction that is linked with traumatic experiences during childhood. This response pattern is altered by oxytocin, possibly by reducing stress and inhibiting social withdrawal from distressing social stimuli.
Martin Brüne; Andreas Ebert; Meike Kolb; Cumhur Tas; Marc-Andreas Edel; Patrik Roser
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human psychopharmacology     Volume:  28     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2014-03-28     Completed Date:  2014-10-09     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  552-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
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MeSH Terms
Borderline Personality Disorder / drug therapy*,  physiopathology
Case-Control Studies
Facial Expression*
Oxytocin / therapeutic use*
Severity of Illness Index
Social Perception*
Wounds and Injuries / epidemiology
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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